YASUDA Toshihiro

FacultyPresident / Vice-president
Teacher OrganizationPresident / Vice-president
Education and
 Research Organization
President / Vice-president
Position
Last Updated: 19/07/23 18:51

Researcher Profile & Settings

Name

    YASUDA Toshihiro

Affiliation

  •  President / Vice-president
  •  Biochemistry and Bioinformative Sciences, Medical Genetics and Biochemistry Professor
  •  University of Fukui
  •  Translational Research Program

Education

  • 1982The University of Tokyo 生物化学
  • 1977The University of Tokyo

Degree

  • Ph.D.

Academic & Professional Experience

  • 1982-1984 National Research Institute of Police Science, Researcher 1984-1989 Fukui Medical University, Research Assistant 1989-1996 Fukui Medical University, Assistant Professor 1996-2000 Gunma University School of Medicine, Assistant Professor 2000- Fukui Medical University, Professor

Research Activities

Published Papers

  • Analysis of copy number variation in the NEDD4L gene potentially implicated in body height in the Japanese population
    M.Ueki, H.Takeshita, J.Fujihara, K.Kimura, R.Iida, T.Yasuda
    Legal Med. Feb.  2019 Refereed
  • Assocation of SNPs in transferrin and transferrin receptor genes with blood iron levels in human
    J. Fujihara, T. Yasuda, K. Kimura, H. Takeshita
    Legal Med 36(1) 17-20 Oct.  2018 Refereed
  • Knockout of Mpv17-like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1 and LIG3 at the Protein Levels.
    R. Iida, M. Ueki, T. Yasuda.
    Oxidative Medicine and Cellular Longevity 2018 Sep.  2018 Refereed
  • Discrimination between infant and adult bloodstains using micro-Raman spectroscopy: A preliminary study.
    J. Fujihara, H. Takeshita, K. Kimura, T. Yasuda, N. Nishimoto.
    J. Forensic Sci. Aug.  2018 Refereed
  • Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans
    J. Fujihara, T. Yasuda, K.Kimura-Kataoka,Y.Takinami, M. Nagao, H.Takeshita
    Legal Med Dec.  2017 Refereed
  • Two fatal cases of caffeine poisoning and a review of the literature
    Junko FUJIHARA , Toshihiro YASUDA, Kaori KIMURA-KATAOKA , Masanori HASEGAWA , Satsuki KURATA, Haruo TAKESHITA
    Shimane J Med Sci Sep.  2017 Refereed
  • Survey of Single-Nucleotide Polymorphisms in the Gene Encoding Human Deoxyribonuclease I-like 2 Producing Loss of Function Potentially Implicated in the Pathogenesis of Parakeratosis
    M. Ueki, H.Takeshita, N.Utsunomiya, T. Chino, N. Oyama, M. Hasegawa, K.i Kimura-Kataoka, J. ujihara, R. Iida, T. Yasuda
    PLoS ONE 12(4) e0175083 Apr.  2017 Refereed
  • An autopsy case of spontaneous esophageal perforation (Boerhaave syndrome)
    K.Kimura, J.Fujihara, S.Kurata, Y.Takinami, K.Inoue, T.Yasuda, H.Takeshita
    Leg Med 23(1) 5-9 Nov.  2016 Refereed
  • Functional single nucleotide polymorphisms (SNPs) in the genes encoding the human deoxyribonuclease (DNase) family potentially relevant to autoimmunity
    M. Ueki, J. Fujihara, K. Kimura, R. Iida, H. Takeshita, T. Yasuda
    Immunol Invest 45(5) 406-419 Jul.  2016 Refereed
  • Association of XRCC1 polymorphisms with arsenic methylation
    J.Fujihata, T.Yasuda, H.Iwata, S.Tanabe, H.Takeshita
    Arch Toxicol 90(4) 1009-1012 Apr.  2016 Refereed
  • Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes
    M.Ueki, K.Kimura, J.Fujihara, H.Takeshita, R.Iida, T.Yasuda
    Gene 561(1) 15-22 Apr.  2015 Refereed
  • Distribution and toxicity evaluation of ZnO dispersion nanoparticles in single intravenously exposed mice
    J. Fujihara, M.Tongu, H.Hashimoto, T.Yamada, K.Kimura, T.Yasuda, Y.Fujita, H.Takeshita
    J Med Invest 62(1/2) 45-60 Feb.  2015 Refereed
  • World-wide distribution of four SNPs in X-ray and repair and cross-complementing group 1 (XRCC1)
    H.Takeshita, J.Fujihara, T.Yasuda, K.Kimura-Kataoka
    ClinTranslational Sci 8(4) 347-350 Aug.  2015 Refereed
  • Distribution of the rs3136794 polymorphism of the DNA polymerase beta gene, involved in the base excision repair pathway, in world-wide population
    K.Kimura, T.Yasuda, J.Fujihara, M.Ueki, H.Takeshita
    Indian J Clin Biochem 30(4) 445-448 Oct.  2015 Refereed
  • Global analysis of genetic variations in a 56-bp variable number of tandem repeat polymorphisms within the human deoxyribonuclease I gene
    J. Fujihara, T.Yasuda, R. Iida, M.Ueki, R.Sano, Y.Kominato, K.Kimura, H.Takeshita
    Leg Med 17(4) 283-286 Jul.  2015 Refereed
  • Pro-inflammatory responses and oxidative stress induced by ZnO nanoparticles in vivo following intravenous injection
    J.Fujihara, M.Tongu, H.Hashimoto, Y.Fujita, T.Yasuda, H.Takeshita
    Eur Rev Med Pharmacol Sci 19(14) 4920-4926 Dec.  2015 Refereed
  • Fatal Hypothermia in Summer
    K.Kimura-Kataoka, J.Fujihara, T.Yasuda, H.Takeshita
    Shimane J Med Sci 31(1) 7-11 Dec.  2014 Refereed
  • Identification of the Functional Alleles of the Nonsynonymous Single-Nucleotide Polymorphisms Potentially Implicated in Autoimmunity in the Human Deoxyribonuclease I Gene
    M.Ueki, K.Kataoka, J.Fujihara, H.Takeshita, R. Iida, Y.Kawai, T.Yasuda
    DNA Cell Biol 33(8) 492-502 Aug.  2014 Refereed
  • DNase I-like 2遺伝子の非同義置換型SNPは尋常性乾癬など不全角化病変のリスクファクターである
    藤原 純子, 木村 かおり, 竹下 治男, 飯田 礼子, 植木 美鈴, 安田 年博
    DNA Polymorphism 22(1) 187-191 Jul.  2014 Not refereed
  • ABO遺伝子血球系特異的エンハンサー内GATAサイトの一塩基置換がB抗原量の低下をもたらしたBm型一症例
    佐野 利恵, 中島 たみ子, 高橋 遙一郎, 藤原 純子, 竹下 治男, 安田 年博, 岸田 哲子
    DNA Polymorphism 22(1) 109-113 Jul.  2014 Not refereed
  • Evaluation of All Non-Synonymous Single Nucleotide Polymorphisms (SNPs) in the Gene Encoding Human Deoxyribonuclease I-like 1, Possibly Implicated in the Blocking of Endocytosis-Mediated Foreign Gene Transfer
    M.Ueki, K.Kimura, J.Fujihara, H.Takeshita, R. Iida, T.Yasuda
    DNA Cell Biol 33(2) 79-87 Feb.  2014 Refereed
  • ABO chimerism with a minor allele detected by the PNA-mediated PCR clamping method
    R.Sano, Y.Takahashi, T.Nakajima, M.Yoshii, R.Kubo, K.Takahashi, Y.Kominato, H.Takeshita, H.Tsuneyama, T.Yasuda, M.Uchiyama, K.Isa, K.Ogasawara
    Blood Transfusion 12(3) 431-434 Feb.  2014 Refereed
  • Evaluation of all non-synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a functional SNP potentially implicated in autoimmunity
    M.Ueki, K.Kimura, H.Takeshita, J.Fujihara, R.Iida, R.Sano, T.Nakajima, Y.Kiominato, Y.Kawai, T.Yasuda
    FEBS J 281(1) 376-390 Jan.  2014 Refereed
  • Seven non-synonymous single nucleotide polymorphisms (SNPs) in the gene encoding human deoxyribonuclease II may serve as a functional SNP potentially implicated in autoimmune dysfunction
    M.Ueki, K.Kimura, J.Fujihara, H.Takeshita, R. Iida, H.Kato, T.Yasuda
     34(24) 3361-3369 Dec.  2013 Refereed
  • Three non-synonymous single nucleotide polymorphisms in the RhitH gene cause reduction of the repression activity that leads to up-regulation of M-LPH, a participant in mitochondrial function
    R. Iida, M. Ueki, J.Fujiwara, H. Takeshita, K. Kimura-Kataoka, T. Yasuda
     2(6) 440-447 Dec.  2013 Refereed
  • Mutation of the GATA site in the erythroid cell-specific regulatory element of the ABO gene in a Bm subgroup individual
    T.Nakajima, R.Sano, Y.Takahashi, R.Kubo, K.Takahashi, Y.Kominato, J.Tsukada, H.Takeshita, T.Yasuda, M.Uchikawa, K.Isa, K.Ogasawara
     53(11) 2917-2927 Nov.  2013 Refereed
  • Accuracy and usefulness of the AVOXimeter 4000 as routine analysis of carboxyhemoglobin
    J.Fujihara, H.Kinoshita, N.Tanaka, T.Yasuda, H.Takeshita
     58(4) 1047-1049 Jul.  2013 Refereed
  • Six VKORC1 polymorphisms for Asians and its survey on ethnic wide-ranging populations
    J.Fujihara, T.Yasuda, K.Kimura, R.Sano, T.Nakajima, Y.Kominato, H.Takeshita
     21 284-290 May  2013 Refereed
  • Fatal butane inhalation from gas cartridges: a case reprot and literature review
    K.Kimura, J.Fujihara, T.Yasuda, H.Takeshita
    Romanian J Legal Med 24(2) 115-120 Jun.  2015 Refereed
  • Association of a single nucleotide polymorphism (rs6180) in GHR gene with plural tissue weight
    J.Fujihara, K. Kimura-Kataoka, T. Yasuda, R. Sano, Y. Kominato, H. Takeshita
    J. Genetics 95(1) 189-192 Mar.  2016 Refereed
  • 自己免疫疾患関連DNase I遺伝子におけるfunctional SNPs;遺伝的リスクファクターの検索
    藤原純子、木村かおり、竹下治男、飯田礼子、河合康幸、植木美鈴、安田年博
    DNA Polymorphism 23(1) 185-190 Jul.  2015 Not refereed
  • Comparison of acute toxicity of ZnO and silica-coated ZnO nanoparticles in mice afrer single intravenous imjection; preliminary experiment to apply to biological imaging
    M.Tongu, H.Hashimoto, T.Yamada, K.Kimura, T.Yasuda, H.Akiyoshi, Y.Fujita, H.Takeshita, J.Fujihara
    Shimane J Med Sci 31(1) 7-11 Dec.  2014 Refereed
  • Identification of interacting partners of human Mpv17-like protein with a mitigating effect of mitochondrial dysfunction through mtDNA damage
    R. Iida, M. Ueki, T. Yasuda
    Free Rad Biol Med 87(1) 336-345 Oct.  2015 Refereed
  • Blood identification and discrimination of human and nonhuman using portable Raman spectroscopy
    J. Fujihara, Y. Fujita , T. Yamamoto, N. Nishimoto, K. Kumira-Kataoka, S. Kurata, T. Yasuda, H. Takeshita
    Int J Legal Med 131(2) 319-322 Mar.  2017 Refereed
  • 尋常性乾癬など不全角化病変のリスクファクターとなるDNase I-like 2遺伝子におけるfunctional SNPsの同定
    藤原純子、木村かおり、竹下治男、飯田礼子、尾山徳孝、知野剛直、長谷川稔、植木美鈴、安田年博
    DNA Polymorphism 24(1) 208-213 Sep.  2016 Not refereed
  • ABO式血液型遺伝子エンハンサーハプロタイプの型特異性
    中島たみ子、佐野理恵、高橋遙一郎、小湊慶彦、竹下治男、安田年博
    DNA Polymorphism 24(1) 214-217 Sep.  2016 Not refereed
  • Simple screening method for copy number variations associated with physical features
    Misuzu Ueki,H. Takeshita, J. Fujihara, R. Iida, T. Yasuda
    Legal Med 25(1) 71-74 Mar.  2017 Refereed
  • Evaluation of all non-synonymous single nucleotide polymorphisms (SNPs) in the genes encoding human deoxyribonuclease I and I-like 3 as a functional SNP potentially implicated in autoimmunity
    Ueki, Misuzu;Kimura-Kataoka, Kaori;Takeshita, Haruo;Fujihara, Junko;Iida, Reiko;Sano, Rie;Nakajima, Tamiko;Kominato, Yoshihiko;Kawai, Yasuyuki;Yasuda, Toshihiro
    FEBS JOURNAL 281(1) 376-390 2014
  • Evaluation of All Nonsynonymous Single-Nucleotide Polymorphisms in the Gene Encoding Human Deoxyribonuclease I-Like 1, Possibly Implicated in the Blocking of Endocytosis-Mediated Foreign Gene Transfer
    Ueki, Misuzu;Kimura-Kataoka, Kaori;Fujihara, Junko;Takeshita, Haruo;Iida, Reiko;Yasuda, Toshihiro
    DNA AND CELL BIOLOGY 33(2) 79-87 2014
  • Identification of the Functional Alleles of the Nonsynonymous Single-Nucleotide Polymorphisms Potentially Implicated in Systemic Lupus Erythematosus in the Human Deoxyribonuclease I Gene
    Kimura-Kataoka, Kaori;Ueki, Misuzu;Takeshita, Haruo;Fujihara, Junko;Iida, Reiko;Kawai, Yasuyuki;Yasuda, Toshihiro
    DNA AND CELL BIOLOGY 33(8) 492-502 2014
  • Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes
    Ueki, Misuzu;Takeshita, Haruo;Kimura-Kataoka, Kaori;Fujihara, Junko;Iida, Reiko;Yasuda, Toshihiro
    GENE 561(1) 15-22 2015
  • Fatal butane inhalation from gas cartridges: a case report and literature review
    Kimura-Kataoka, Kaori;Fujihara, Junko;Yasuda, Toshihiro;Takeshita, Haruo
    ROMANIAN JOURNAL OF LEGAL MEDICINE 23(2) 115-120 2015
  • Global analysis of genetic variations in a 56-bp variable number of tandem repeat polymorphisms within the human deoxyribonuclease I gene
    Fujihara, Junko;Yasuda, Toshihiro;Iida, Reiko;Ueki, Misuzu;Sano, Rie;Kominato, Yoshihiko;Inoue, Ken;Kimura-Kataoka, Kaori;Takeshita, Haruo
    LEGAL MEDICINE 17(4) 283-286 2015
  • Worldwide Distribution of Four SNPs in X-Ray and Repair and Cross-Complementing Group 1 (XRCC1)
    Takeshita, Haruo;Fujihara, Junko;Yasuda, Toshihiro;Kimura-Kataoka, Kaori
    CTS-CLINICAL AND TRANSLATIONAL SCIENCE 8(4) 347-350 2015
  • Identification of interacting partners of Human Mpv17-like protein with a mitigating effect of mitochondrial dysfunction through mtDNA damage
    Iida, Reiko;Ueki, Misuzu;Yasuda, Toshihiro
    FREE RADICAL BIOLOGY AND MEDICINE 87 336-345 2015
  • Distribution and toxicity evaluation of ZnO dispersion nanoparticles in single intravenously exposed mice
    Fujihara Junko;Tongu Miki;Hashimoto Hideki;Yamada Takaya;Kimura-Kataoka Kaori;Yasuda Toshihiro;Fujita Yasuhisa;Takeshita Haruo
    J. Med. Invest. 62(1) 45-50 2015
    ZnO nanoparticles (NPs) have been widely used in various commercial products. Application of ZnO NPs is expected to apply to cancer diagnosis and therapy, used as drug delivery carriers. In the present study, the lethal dose 50 (LD50) of intravenously administered ZnO NPs (0.3 mg/kg) was calculated in mice. Blood kinetics and tissue distribution of a toxic dose of ZnO NPs (0.2 mg/kg, 0.05 mg/kg) were investigated after intravenous exposure. In addition, 8-hydroxy-2-deoxyguanosine (8-OHdG) was evaluated. Following the injection, ZnO NPs were rapidly removed from the blood and distributed to organs. Pulmonary emphysema was observed pathologically study in mice at 3 days after the 0.2 mg/kg dose and at 6 days after the 0.05 mg/kg dose. ZnO NPs were mainly accumulated in the lung and spleen within 60 min. From the long-term tissue distribution study, the liver showed peak concentration at 6 days, and spleen peaked at 1 day. The lungs kept high levels until 6 days. Tissue distribution and pathological study showed that the spleen, liver, and lungs are target organs for ZnO NPs. Accumulation in the liver and spleen may be due to the phagocytosis by macrophages. A dose-dependent increase in 8-OHdG was observed in mice treated with ZnO NPs. This study is the first to show information on kinetics and target organs following intravenous ZnO injection. J. Med. Invest. 62: 45-50, February, 2015
  • An autopsy case of spontaneous esophageal perforation (Boerhaave syndrome).
    Kimura-Kataoka Kaori;Fujihara Junko;Kurata Satsuki;Takinami Yoshikazu;Inoue Ken;Yasuda Toshihiro;Takeshita Haruo
    Legal medicine (Tokyo, Japan) 23 2016
    :A 45-year-old male, an alcohol addict with asthma, was found dead in his home, after several days of continued drinking. A forensic autopsy was performed 3days after the discovery of his death in order to specify the cause of death. A longitudinal perforation penetrating all layers of the esophagus measuring 1.8cm was present on the left wall approximately 2.0cm from the gastroesophageal junction. There were 1900mL of greenish to brownish turbid liquid in the left pleural cavity and 150mL of greenish viscous liquid in the stomach. Histopathologically, an infiltration of numerous neutrophils was evident in the submucosa layer, proper muscular layer, and serous membrane of the esophagus, corresponding to the esophageal laceration. The serum C-reactive protein (CRP) concentration was determined to be 3.1mg/dL. The alcohol concentrations were determined to be 1.49mg/g in the right cardiac blood, 1.31mg/g in the left cardiac blood, and 2.48mg/g in urine. Based upon the autopsy and histopathological findings, as well as the biochemical and toxicological analyses, we concluded that the cause of death was respiratory failure by pleural effusion, resulting from spontaneous esophageal perforation. This was the first report of a spontaneous esophageal perforation eventually causing respiratory failure.
  • Functional Single Nucleotide Polymorphisms (SNPs) in the Genes Encoding the Human Deoxyribonuclease (DNase) Family Potentially Relevant to Autoimmunity.
    Fujihara Junko;Ueki Misuzu;Kimura-Kataoka Kaori;Iida Reiko;Takeshita Haruo;Yasuda Toshihiro
    Immunological investigations 45(5) 2016
    OBJECTIVE:To continue our previous investigations, we have extensively investigated the function of the 61, 41, and 35 non-synonymous single nucleotide polymorphisms (SNPs) in the human genes encoding DNASE1, DNASE1L3, and DNASE2, respectively, potentially relevant to autoimmune diseases.;METHODS:The site-directed mutagenesis was employed to amino acid-substituted constructs corresponding to each SNP. The COS-7 cells were transfected with each vector and DNase activity was assayed by the single radial enzyme diffusion method. By using PolyPhen-2, changes in the DNase function of each non-synonymous SNP were predicted. Genotyping of all the non-synonymous SNPs was performed in 14 different populations including 3 ethnic groups using the polymerase chain reaction followed by the restriction fragment length polymorphism method.;RESULTS:Expression analysis demonstrated these SNPs to be classified into four categories with regard to the effect on DNase activity: SNPs not affecting the activity level, ones reducing it, ones abolishing it, and ones elevating it. In particular, 9, 5, and 4 SNPs producing a loss-of-function variant of the enzymes in DNASE1, DNASE1L3, and DNASE2, respectively, were confirmed. SNPs producing DNase loss of function can be estimated by PolyPhen-2 to be "probably damaging" with a high accuracy of prediction. Almost all of these functional SNPs producing a loss of function or substantially low activity-harboring forms exhibited a mono-allelic distribution in all of the populations.;CONCLUSION:A minor allele of functional SNPs, despite the remarkably low genetic heterogeneity of the SNPs, might be a genetic risk factor for autoimmune diseases.
  • An autopsy case of spontaneous esophageal perforation (Boerhaave syndrome)
    Kimura-Kataoka, Kaori;Fujihara, Junko;Kurata, Satsuki;Takinami, Yoshikazu;Inoue, Ken;Yasuda, Toshihiro;Takeshita, Haruo
    LEGAL MEDICINE 23 5-9 Nov.  2016
  • Simple screening method for copy number variations associated with physical features.
    Ueki Misuzu;Takeshita Haruo;Fujihara Junko;Kimura-Kataoka Kaori;Iida Reiko;Yasuda Toshihiro
    Legal medicine (Tokyo, Japan) 25 2017
    :Recent studies of copy number variations (CNVs) associated with physical features, such as body mass index, body height or bone length, have suggested that such CNVs could serve as markers in forensic cases involving unidentified individuals. However, the process of cataloging CNVs has been slow because of the cumbersome nature and low reliability of the procedures involved. Here we describe a simple quantitative real-time PCR (Q-PCR) method for screening of medicolegally useful CNVs, which does not require reference DNA with known copy number. The first step is to prepare a chimeric plasmid vector including one copy each of the single-copy gene-specific sequence as the internal standard, and the target CNV-specific sequence. To assess the validity of this new method, we analyzed CNVs in the LTBP1 and ETV6 gene regions, both of which are candidate CNVs associated with body height. The PCR efficiencies for the single-copy (reference) gene and the target CNV were similar, indicating that quantitation was reliable. Furthermore, simulated analysis of the LTBP1 CNV using mock samples prepared by mixing vectors in varying proportions showed that this analytical method allowed correct determination of the LTBP1 copy number. These results demonstrated that our simple method has considerable potential for screening of trait-related CNVs that would be useful for forensic casework.
  • Identification of novel variants in HLA class II region related to HLA DPB1 expression and disease progression in patients with chronic hepatitis C
    Hiramatsu, Katsushi;Matsuda, Hidetaka;Nemoto, Tomoyuki;Nosaka, Takuto;Saito, Yasushi;Naito, Tatsushi;Takahashi, Kazuto;Ofuji, Kazuya;Ohtani, Masahiro;Suto, Hiroyuki;Yasuda, Toshihiro;Hida, Yukio;Kimura, Hideki;Soya, Yoshihiro;Nakamoto, Yasunari
    JOURNAL OF MEDICAL VIROLOGY 89(9) 1574-1583 Sep.  2017
  • Association of SNPs in genes encoding zinc transporters on blood zinc levels in humans.
    Fujihara Junko;Yasuda Toshihiro;Kimura-Kataoka Kaori;Takinami Yoshikazu;Nagao Masataka;Takeshita Haruo
    Legal medicine (Tokyo, Japan) 30 2017
    :Zinc homeostasis in cells depends on zinc transporters, which are divided into 2 families: ZnT (SLC30A) and ZIP (SLC39A). In this study, we examined the effect of 20 single nucleotide polymorphisms (SNPs) in 10 genes encoding zinc transporters on blood zinc concentration in Japanese subjects (n = 102). Blood zinc levels were determined by microwave plasma-atomic emission spectrometry, and SNPs were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism analysis. Among the 20 SNPs examined, 3 SNPs (SLC30A3 rs11126936, SLC39A8 rs233804, and SLC39A14 rs4872479) were significantly associated with blood zinc concentration. Individuals with genotype TT and TG in rs11126936 showed significantly higher blood zinc concentrations than those with GG. As for rs233804, individuals harboring the A allele had significantly higher blood zinc concentrations than those without this allele. Furthermore, the genotype TT and TG in rs4872479 had significantly higher blood zinc concentrations than those with GG. Among these three SNPs, combination of SLC30A3 rs11126936 and SLC39A8 rs233804 may strongly affect blood zinc levels. This study is the first comprehensive investigation of the effect of SNPs in genes encoding zinc transporters on blood zinc concentration. Adverse effects of zinc deficiency are reported and above 3 SNPs may be related to genetic susceptibility to zinc deficiency.
  • Analysis of copy number variation in the NEDD4L gene potentially implicated in body height in the Japanese population
    M. Ueki, H. Takeshita, J. Fujihara, K. Kimura, R. Iida, T. Yasuda
    Leg Med 37 83-85 Feb.  2019 Refereed

Conference Activities & Talks

  • 心疾患患者の血清中cell-free DNA濃度とDNase I活性の関連
    藤原 純子、瀧波 慶和、竹下 治男、木村 かおり、飯田 礼子、植木 美鈴、安田 年博
    第27回日本DNA多型学会学術集会 Dec.  2018
  • 死後血中cell-free DNAに関する予備的検討
    藤原 純子、竹下 治男、木村 かおり、飯田 礼子、安田 年博
    第27回日本DNA多型学会学術集会 Dec.  2018
  • DNase familyの遺伝的多型および酵素活性解析
    木村 かおり、藤原 純子、山田 和夫、飯田 礼子、植木 美鈴、安田 年博、竹下 治男
    第27回日本DNA多型学会学術集会 Dec.  2018
  • 定量的real-time PCRを用いた簡便なCNV解析法の応用―NEDD4L遺伝子
    飯田 礼子、植木 美鈴、竹下 治男、藤原 純子、木村 かおり、安田 年博
    第27回日本DNA多型学会学術集会 Dec.  2018
  • タンパク多型からDNA多型へ―DNase遺伝子を中心に
    安田年博
    第27回日本DNA多型学会学術集会 Dec.  2018
  • 死後画像検査および司法解剖を施行した体位性窒息死の1例
    木村かおり、藤原純子、山田和夫、安田年博、竹下治男
    第35回日本法医学会学術中四国地方集会 Oct.  2018
  • Survey of cipy number variations (CNVs) associated with body height
    T. Yasuda, R. Iida, M. Ueki, J. Fujihara, K. Kimura, K. Yamada, H. Takeshita
    24th Congress of the International Academy of Legal Medicine Jun.  2018
  • Discrimination between adults and infant bloodstains using Raman spectropscopy
    J. Fujihara, N. Nishimoto, Y. Fujita, T. Yamamoto, K. Kimura, T. Yasuda, H. Takeshita.
    24th Congress of the International Academy of Legal Medicine Jun.  2018
  • Interleukin8-251A>T polymorphism (rs4073) in Japanese populations and its correlation with smoking rates.
    K. Kimura, M. Ueki, T. Yasuda, R. Iida, J. Fujihara, K. Yamada, R. Sano, Y. Kominato, H. Takeshita.
    24th Congress of the International Academy of Legal Medicine Jun.  2018
  • 質量分析を用いたストレスマーカーの一斉定量法とその法医解剖への応用に向けて
    山田和夫、藤原純子、木村かおり、松木健一、安田年博、竹下治男
    第33回日本法医学会学術中四国地方集会 Oct.  2016
  • UV照射後のp型・n型酸化亜鉛ナノ粒子毒性精査
    藤原純子、木村かおり、竹下治男、藤田恭久、安田年博
    第33回日本法医学会学術中四国地方集会 Oct.  2016
  • 塩基除去修復(BER)経路に関わるDNA polymerase beta (POLB)遺伝子多型の世界分布
    木村かおり、藤原純子、山田和夫、安田年博、竹下治男
    日本DNA多型学会第26回学術集会 Nov.  2017
  • Endoplasmic reticulum aminopeptidase 1 (ERAP1)遺伝子におけるSNP (rs27434)と臓器重量等との関連
    山田和夫、藤原純子、竹下治男、木村かおり、安田年博
    DNA多型学会第26回学術集会 Nov.  2017
  • 心疾患患者における血清中cell-free DNAに関する予備的検討
    藤原純子、瀧波慶和、竹下治男、木村かおり、安田年博、倉田さつき
    日本DNA多型学会第26回学術集会 Nov.  2017
  • 国内外の多集団におけるInterleukin 8遺伝子 (CXCL8) 内 -251 A/T 多型解析 においてみられた地理的勾配および喫煙率との相関
    竹下治男、藤原純子、木村かおり、山田和夫、安田年博
    日本法医学会第34回学術中・四国地方集会 Oct.  2017
  • GaSb薄膜の毒性評価
    藤原純子、西本尚巳、安田年博、長谷川正紀、竹下治男
    日本法中毒会第36年会 Jul.  2017
  • 自己免疫疾患に関与するヒトDNase family遺伝子のfunctional SNPs
    安田年博、飯田礼子、植木美鈴、竹下治男、藤原純子、木村かおり、山田和夫、河合康幸
    第101次日本法医学会学術全国集会 Jun.  2017
  • 血中ZnおよびFe濃度に関与する遺伝子多型部位の予備的検索
    藤原純子、木村かおり、竹下治男、倉田さつき、安田年博
    第101次日本法医学会学術全国集会 Jun.  2017
  • SIDSにて死亡した第1子、Shaken Baby Syndromeであった第2子の同胞
    木村かおり、藤原純子、山田和夫、長谷川有紀、倉田さつき、安田年博、竹下治男
    第101次日本法医学会学術全国集会 Jun.  2017
  • 急性カフェイン中毒死と考えられる一例
    藤原純子, 木村かおり, 長谷川正紀, 安田 年博, 竹下治男
     Dec.  2014
  • 酸化亜鉛ナノ粒子の静脈投与による毒性影響
    藤原純子, 木村かおり, 竹下治男, 安田 年博
    第30回日本法医学会学術中四国地方集会 Nov.  2014
  • HMGA2、LHX3-QSOX2及びIGF1遺伝子多型:日本人身長・臓器重量との関連性および民族差異について
    竹下治男, 藤原純子, 木村かおり, 仲田佐和子, 安田 年博
    第30回日本法医学会学術中四国地方集会 Nov.  2014
  • ヒ素のメチル化能に関するXRCC1多型とその頻度の世界比較
    藤原 純子, 竹下 治男, 木村 かおり, 植木 美鈴, 飯田 礼子, 安田 年博
    日本DNA多型学会第23回学術集会 Nov.  2014
  • 自己免疫疾患関連DNase I遺伝子におけるfunctional SNPs;遺伝的リスクファクターの検索
    藤原 純子, 竹下 治男, 木村 かおり, 植木 美鈴, 飯田 礼子, 安田 年博, 河合 康幸
    日本DNA多型学会第23回学術集会 Nov.  2014
  • 多型性DNase I遺伝子におけるfunctional SNPsの同定
    安田 年博, 飯田 礼子, 竹下 治男, 木村 かおり, 藤原 純子
    第98次日本法医学会学術全国集会 Jun.  2014
  • Mutations were found in the transcription-regulatory elements such as the promoter and the erythroid cell-specific enhancer of ABO in individuals with phenotypes Am, A3 and B3
    Y.Takahashi, R.Sano, T.Nakajima, H.Takeshita, T.Yasuda, Y.Kominato
    9th International Symposium on Advances in Legal Medicine Jun.  2014
  • Genetic and expression analysis of all the nonsynonymous and autoimmunity-related SNPs in the human deoxyribonuclease II gene
    K.Kimura, M.Ueki, Y.Takahashi, R. Iida, T.Yasuda, R.Sano, Y.Kominato, T.Nakajima, H.Kato, H.Takeshita
    9th International Symposium on Advances in Legal Medicine Jun.  2014
  • A case of death in a bathtub from hypothermia even in medsummer
    K.Kimura, J.Fujihara, M.Ueki, T.Yasuda, R. Iida, Y.Takahashi, R.Sano, Y.Kominato, H.Takeshita
    9th International Symposium on Advances in Legal Medicine Jun.  2014
  • ABO chimerism with a minor allele detected by the PNA-mediated PCR clamping method
    R.Sano, Y.Takahashi, T.Nakajima, Y.Kominato, H.Takeshita, T.Yasuda
    9th International Symposium on Advances in Legal Medicine Jun.  2014
  • Growth hormone receptor (GHR)遺伝子におけるSNP (rs6180)と臓器重量との相関
    藤原純子、竹下治男、木村かおり、植木美鈴、安田年博、佐野理恵、小湊慶彦、倉田さつき
    日本DNA多型学会第24回学術集会 Nov.  2015
  • p型およびn型半導体ZnOナノ粒子の毒性評価
    藤原純子、藤田恭久、安田年博、長谷川正紀、竹下治男
    日本法中毒学会第35年会 Jul.  2016
  • 特発性食道破裂(Boerhaave症候群)の一剖検例
    木村かおり、藤原純子、竹下治男、倉田さつき、安田年博
    第100次日本法医学会学術全国集会 Jun.  2016
  • ポータブルラマン分光器を用いた血痕の人獣鑑別法の予備的検討
    藤原純子、木村かおり、竹下治男、瀧波慶和、安田年博
    第100次日本法医学会学術全国集会 Jun.  2016
  • ヒト年齢依存性生体分子M-LPの機能解析
    安田年博、飯田礼子、植木美鈴、竹下治男、小湊義彦
    第100次日本法医学会学術全国集会 Jun.  2016
  • ABO式血液型遺伝子エンハンサーのハプロタイプはABO遺伝子型とリンクしている
    中島たみ子、佐野理恵、高橋陽一郎、竹下治男、安田年博、小湊義彦
    第100次日本法医学会学術全国集会 Jun.  2016
  • モノグラフが書ける研究を目指してーdeoxyribonuclease Iを基軸として
    安田年博
    第38回日本法医学会学術中部地方集会 Oct.  2016
  • 法医学的個人識別に有用なCNVのスクリーニング
    飯田礼子、安田年博、植木美鈴、竹下治男、藤原純子、木村かおり
    日本DNA多型学会第25回学術集会 Dec.  2016
  • ポータブルラマン分光器を用いた非破壊の血痕検査法と人獣鑑別法の確立
    藤原純子、竹下治男、木村かおり、藤田恭久、安田年博、倉田さつき
    日本DNA多型学会第25回学術集会 Dec.  2016
  • 日本国内および世界人口におけるインターロイキン8内-251A/T多型解析
    木村かおり、藤原純子、安田年博、倉田さつき、小湊慶彦、佐野理恵、山田和夫、竹下治男
    日本DNA多型学会第25回学術集会 Dec.  2016
  • Nano-LC/MS/MSを用いたテネイシンX欠損型エーラスダンロス症の診断法の開発
    山田和夫、渡辺淳、木村かおり、藤原純子、安田年博、竹下治男、松木健一
    日本DNA多型学会第25回学術集会 Dec.  2016
  • 尋常性乾癬など不全角化病変のリスクファクターとなるDNase I-like 2遺伝子におけるfunctional SNPsの同定
    藤原純子、竹下治男、木村かおり、植木美鈴、飯田礼子、安田年博、倉田さつき
    日本DNA多型学会第24回学術集会 Nov.  2015
  • ABO式血液型遺伝子エンハンサーハプロタイプの型特異性
    中島たみ子、佐野理恵、高橋洋一郎、小湊慶彦、竹下治男、安田年博
    日本DNA多型学会第24回学術集会 Nov.  2015
  • 酸化亜鉛ナノ粒子の静脈投与後の毒性検査
    藤原純子、木村かおり、竹下治男、飯田礼子、安田年博、佐野理恵、小湊慶彦
    第99次日本法医学会学術全国集会 Jun.  2015
  • Bm型では赤血球系細胞においてB遺伝子発現が極めて低下している
    佐野理恵、中島たみ子、高橋洋一郎、竹下治男、安田年博、岸田哲子、小湊慶彦
    第99次日本法医学会学術全国集会 Jun.  2015
  • カセットボンベを用いたブタン吸引による窒息死の1例
    木村かおり、藤原純子、竹下治男、長谷川正紀、安田年博
    第99次日本法医学会学術全国集会 Jun.  2015
  • 司法解剖前後の死後画像検査確認および対比を行った腐敗漂流死体の1例
    木村かおり、藤原純子、竹下治男、金山秀和、北垣一、安田年博
    第99次日本法医学会学術全国集会 Jun.  2015
  • 有機リン中毒が関与した法医学解剖4事例
    藤原純子、木村かおり、長谷川正紀、安田年博、小湊慶彦、中島たみ子、佐野理恵、高橋洋一郎、竹下治男
    第37回日本中毒学会総会・学術集会 Jul.  2015
  • DNase I遺伝子内VNTR多型頻度分布の世界比較
    藤原純子、木村かおり、竹下治男、安田年博、倉田さつき
    第32回日本法医学会学術中国四国地方集会 Oct.  2015
  • The role of Mpv17-like protein in the maintenance of mitochondrial DNA
    Iida R, Yasuda T, Ueki M, Takeshita H
     Nov.  2018
  • Survey of cipy number variations (CNVs) associated with body height.
    T. Yasuda, R. Iida, M. Ueki, J. Fujihara, K. Kimura, K. Yamada, H. Takeshita
    24th Congress of the International Academy of Legal Medicine Jun.  2018
  • Interleukin8-251A>T polymorphism (rs4073) in Japanese populations and its correlation with smoking rates.
    K. Kimura, M. Ueki, T. Yasuda, R. Iida, J. Fujihara, K. Yamada, R. Sano, Y. Kominato, H. Takeshita
    24th Congress of the International Academy of Legal Medicine Jun.  2018

Awards & Honors

  •  日本DNA多型学会 優秀研究賞Dec. 2017