IWAMOTO Masayuki

FacultyBiochemistry and Bioinformative Sciences, Molecular Neuroscience
Teacher OrganizationBiochemistry and Bioinformative Sciences
Education and
 Research Organization
Faculty of Medical Sciences, School of Medicine
PositionProfessor
Last Updated: 19/07/23 18:50

Researcher Profile & Settings

Name

    IWAMOTO Masayuki

Affiliation

  •  Biochemistry and Bioinformative Sciences, Molecular Neuroscience Professor

Academic & Professional Experience

  • Apr. 2007Dec. 2018福井大学 Assistant Professor

Research Activities

Published Papers

  • In bulla functional channel expression systems that mimic bacterial synthetic membranes.
    Iwamoto Masayuki;Oiki Shigetoshi
    Method. Enzymol. 621 May  2019 Refereed
  • Drop-in-well chamber for droplet interface bilayer with built-in electrodes.
    Urakubo Kazuhiro;Iwamoto Masayuki;Oiki Shigetoshi
    Method. Enzymol. 621 May  2019 Refereed
  • Lipid Bilayer Experiments with Contact Bubble Bilayers for Patch-Clampers
    Iwamoto, Masayuki;Oiki, Shigetoshi
    J. Vis. Exp.(143) Jan.  2019 Refereed
  • Constitutive boost of a K+ channel via inherent bilayer tension and a unique tension-dependent modality
    Iwamoto, Masayuki;Oiki, Shigetoshi
    Proc. Natl. Acad. Sci. U. S. A. 115(51) 13117-13122 Dec.  2018 Refereed
  • Thylakoid membranes contain a non-selective channel permeable to small organic molecules
    Kojima, Seiji;Iwamoto, Masayuki;Oiki, Shigetoshi;Tochigi, Saeko;Takahashi, Hideyuki
    J. Biol. Chem. 293(20) 7777-7785 May  2018 Refereed
  • Concurrent In Vitro Synthesis and Functional Detection of Nascent Activity of the KcsA Channel under a Membrane Potential
    Iwamoto, Masayuki;Elfaramawy, Maie A.;Yamatake, Mariko;Matsuura, Tomoaki;Oiki, Shigetoshi
    ACS Synth. Biol. 7(4) 1004-1011 Apr.  2018 Refereed
  • Lipid Bilayers Manipulated through Monolayer Technologies for Studies of Channel-Membrane Interplay
    Oiki, Shigetoshi;Iwamoto, Masayuki
    Biol. Pharm. Bull. 41(3) 303-311 Mar.  2018 Refereed
  • Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3
    M.Iwamoto, A.Sumino, E.Shimada, M.Kinoshita, N.Matsumori, S.Oiki
    Sci. Rep. 7 10782 Sep.  2017 Refereed
  • Membrane Perfusion of Hydrophobic Substances Around Channels Embedded in the Contact Bubble Bilayer
    M.Iwamoto, S.Oiki
    Sci. Rep. 7 6857 Jul.  2017 Refereed
  • Structure and Dynamics of Membrane-embedded KcsA Potassium Channel Revealed by Atomic Force Microscopy
    SUMINO Ayumi;YAMAMOTO Daisuke;SUMIKAMA Takashi;IWAMOTO Masayuki;DEWA Takehisa;OIKI Shigetoshi
    Seibutsu Butsuri 55(1) 5-10 2015 Refereed
  • Rectified proton Grotthuss conduction across a long water-wire in the test nano-tube of the polytheonamide B channel
    Matsuki Y, Iwamoto M, Mita K, Shigemi K, Matsunaga S, Oiki S
    J. Am. Chem. Soc. 138 4168-4177 Mar.  2016 Refereed
  • Mechanism for attenuated outward conductance induced by mutations in the cytoplasmic pore of Kir2.1 channels
    Chang HK, Iwamoto M, Oiki S, Shieh RC
    Sci. Rep. 5 18404 Dec.  2015 Refereed
  • pH-dependent promotion of phospholipid flip-flop by the KcsA potassium channel
    Nakao, H., Ikeda, K., M.Iwamoto, H.Shimizu, S.Oiki, Ishihara, Y, Nakano, M.
    Biochim. Biophys. Acta-Biomembr. 1848 145-150 2015 Refereed
  • Contact bubble bilayers with flush drainage
    M.Iwamoto, S.Oiki
     5 9110 Mar.  2015 Refereed
  • Gating-Coupled Clustering-Dispersion Dynamics of the KcsA Potassium Channel in a Lipid Membrane
    Sumino, Ayumi;Yamamoto, Daisuke;Iwamoto, Masayuki;Dewa, Takehisa;Oiki, Shigetoshi
    Biophys. J. 106(2) 746A-746A 2014 Not refereed
  • Gating-associated clustering-dispersion dynamics of the KcsA potassium channel in a lipid membrane
    A.Sumino, D.Yamamoto, M. Iwamoto, T.Dewa, S.Oiki
    J. Phys. Chem. Lett. 5 578-584 Mar.  2014 Refereed
  • Paradoxical one-ion pore behavior of the long β-helical peptide of marine cytotoxic polytheonamide B
    M.Iwamoto, S.Matsunaga, S.Oiki
    Sci. Rep. 4 3636 Jan.  2014 Refereed
  • The Open Gate Structure of the Membrane-Embedded KcsA Potassium Channel Viewed From the Cytoplasmic Side
    A.Sumino, T.Sumikama, M.Iwamoto, T.Dewa, S.Oiki
    Sci. Rep. 3 1063 2013 Refereed
  • Biased Brownian Stepping Rotation of FoF1-ATP Synthase Driven by Proton Motive Force
    R.Watanabe, K.V.Tabata, R.Iino, H.Ueno, M.Iwamoto, S.Oiki, H.Noji
    Nat. Commun. 4 1631 2013 Refereed
  • 脂質二重膜組成がKcsAカリウムチャネル活性に及ぼす影響
    Journal of the Physiological Society of Japan 74 66 Mar.  2012 Not refereed
  • Amphipathic antenna of an inward rectifier K+ channel responds to changes in the inner membrane leaflet
    M.Iwamoto, S.Oiki
     110(2) 749-754 Jan.  2013 Refereed
  • Oriented reconstitution of a membrane protein in vesicles with asymmetric lipid compositions: Experimental verification with the potassium channel KcsA
    M.Yanagisawa, M.Iwamoto, A.Kato, K.Yoshikawa, S.Oiki
    J. Am. Chem.Soc. 133 11774-11779 2011 Refereed
  • Sidedness of the effective phospholipids on the function of the KcsA potassium channel revealed by the single-channel recording in the asymmetric lipid bilayer
    M.Iwamoto, S.Oiki
     62 Suppl s84 Mar.  2012 Not refereed
  • The Asymmetric Lipid Bilayer Revealed Sidedness of the Effective Phospholipids on the Single-Channel Properties of the KcsA Potassium Channel
    M.Iwamoto, S.Oiki
    Biophys. J. 102 537a Jan.  2012 Not refereed
  • Single Molecular Gating Dynamics for KcsA Potassium Channel
    S.Oiki, H.Shimizu, M.Iwamoto, T.Konno
    Adv. Chem. Phys. 146 147-194 Nov.  2011 Refereed
  • Counting ion and water molecules in a streaming file through the open-filter structure of the K channel
    M.Iwamoto, S.Oiki
    J. Neurosci. 31(34) 12180-12188 Aug.  2011 Refereed
  • Cycle Flux Algebra for Ion and Water Flux through the KcsA Channel Single-file Pore Links Microscopic Trajectories and Macroscopic Observables
    S.Oiki, M.Iwamoto, T.Sumikama
    PLoS ONE 6 e16578 Jan.  2011 Refereed
  • A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane
    M.Iwamoto, H.Shimizu, I.Muramatsu, S.Oiki
    FEBS Lett. 584(18) 3995-3999 Sep.  2010 Refereed
  • A mesoscopic approach to understanding the mechanisms underlying the ion permeation on the discrete-state diagram
    S.Oiki, M.Iwamoto, T.Sumikama
    J. Gen. Physiol. 136(3) 363-365 Aug.  2010 Refereed
  • A Cytotoxic Peptide from a Marine Sponge, Polytheonamide B: I. Channel Activity and Vectorial-Insertion Into the Membrane
    M.Iwamoto, H.Shimizu, I.Muramatsu, S.Matsunaga, S.Oiki
     98(3) 110a Jan.  2010 Not refereed
  • A Cytotoxic Peptide from a Marine Sponge, Polytheonamide B; II. Properties for Ion Conduction and Voltage Dependent Gating
    M.Iwamoto, H.Shimizu, I.Muramatsu, S.Matsunaga, S.Oiki
     98(3) 109a Jan.  2010 Not refereed
  • pH-Dependent gating of KcsA potassium channel
    Y.Matsuki, M.Iwamoto, H.Shimizu, S.Oiki
     98(3suppliment1) 314a Jan.  2010 Not refereed
  • Ion distribution in the open KcsA channel evaluated by the streaming potential
    M.Iwamoto, H.Shimizu, S.Oiki
     59 suppl 256 2009
  • The water-ion coupling ratio for ion permeation through the KcsA potassium channel: Dependencies on concentration and species of permeating ions
    M.Iwamoto, H.Shimizu, S.Oiki
     96 suppl 179a 2009
  • Structural changes in the O-decay accelerated mutants of pharaonis phoborhodopsin
    Y.Sudo, Y.Furutani, M.Iwamoto, N.Kamo, H.Kandori
     47 2866-2874 2008 Refereed
  • A Long-lived M-like state of phoborhodopsin which mimics the active state
    Y.Sudo, T.Nishihori, M.Iwamoto, K.Shimono, C.Kojima, N.Kamo
     95 753-760 2008 Refereed
  • Flux coupling between ion and water in the K+ selective pore
    M.Iwamoto, H.Shimizu, S.Oiki
     58 suppl s77 2008 Not refereed
  • Global Twisting Motion of Single Molecular KcsA Potassium Channel Upon Gating
    H. Shimizu, M. Iwanoto, T. Konnno, A. Nihei, Yuji C, Sasaki, S. Oiki
    Cell 132(1) 67-78 Jan.  2008 Refereed
  • Participation of the surface structure of pharaonis phoborhodopsin, ppR and its A149S and A149V mutants, consisting of the C-terminal alpha-helix and E-F loop, in the complex-formation with the cognate transducer pHtrII, as revealed by site-directed 13C solid-state NMR
    I.Kawamura, Y.Ikeda, Y.Sudo, M.Iwamoto, K.Shimono, S.Yamaguchi, S.Tuzi, H.Saito, N.Kamo, A.Naito
    Photochem. Photobiol. 83 339-345 2007 Refereed
  • Inportance of specific hydrogen bonds of archaeal rhodopsins for the binding to the transducer protein
    Y.Sudo, M.Yamabi, S.Kato, C.Hasegawa, M.Iwamoto, K.Shimono, N.Kamo
     357 1274-1282 2006 Refereed
  • Surface structure and its dynamic rearrangements of the KcsA potassium channel upon gating and tetrabutylammonium blocking
    M.Iwamoto, H.Shimizu, F.Inoue, T.Konno, Y.C.Sasaki, S.Oiki
     281 28379-28386 Sep.  2006 Refereed
  • Conformational changes in the cytoplasmic domain of KcsA potassium channel upon gating
    M.Iwamoto, H.Shimizu, F.Inoue, T.Konno, A.Nihei, Y.C.Sasaki, S.Oiki
     56 suppl s157 2006 Not refereed
  • Correlation of the O-intermediate rate with the pKa of Asp-75 in the dark, the counterion of the Schiff base of pharaonis phoborhodopsin (sensory rhodopsin II)
    M.Iwamoto, Y.Sudo, K.Shimono, T.Araiso, N.Kamo
     88 1215-1223 2005 Refereed
  • Probing cytoplasmic domain of single KcsA channel by use of surface plasmon resonance signal and planar lipid bilayer
    M.Iwamoto, H.Shimizu, F.Inoue, T.Konno, Y.C.Sasaki, S.Oiki
     55 suppl s135 2005 Not refereed
  • Proton release and uptake of pharaonis phoborhodopsin (sensory rhodopsin II) reconstituted into phospholipids
    M. Iwanoto, C. Hasegawa, Y. Sudo, K. Shimono, T. Araiso, N. Kamo
     43 3195-3203 2004 Refereed
  • Photochemical properties of pharaonis phoborhodopsin (sensory rhodopsin II)
    M.Iwamoto, H.Kandori, N.Kamo
    Rec. Res. Dev. Chem. 1 15-30 2003 Not refereed
  • Proton transfer reactions in the F86D and F86E mutants of pharaonis phoborhodopsin (sensory rhodopsin II)
    M.Iwamoto, Y.Furutani, N.Kamo, H.Kandori
    Biochemistry 42 2790-2796 2003 Refereed
  • Interaction of Natronobacterium pharaonis phoborhodopsin (sensory rhodopsin II) with its cognate transducer probed by increase in the thermal stability
    Y.Sudo, M.Yamabi, M.Iwamoto, K.Shimono, N.Kamo
    Photochem. Photobiol. 2003 Refereed
  • Importance of the broad regional interaction for spectral tuning in Natronobacterium pharaonis phoborhodopsin (sensory rhodopsin II)
    K.Shimono, T.Hayashi, Y.Ikeura, Y.Sudo, M.Iwamoto, N.Kamo
    J. Biol. Chem. 278 23882-23889 2003 Refereed
  • Arg-72 of pharaonis phoborhodopsin (sensory rhodopsin II) is important for the maintenance of the protein structure in the solubilized state
    Y.Ikeura, K.Shimono, M.Iwamoto, Y.Sudo, N.Kamo
    Photochem. Photobiol. 77 96-100 2003 Refereed
  • Illumination accelerates the decay of the O-intermediate of pharaonis phoborhodopsin (sensory rhodopsin II)
    M.Iwamoto, Y.Sudo, K.Shimono, N.Kamo
    Photochem. Photobiol. 76 462-466 2002 Refereed
  • Role of Asp193 in chromophore-protein interaction of pharaonis phoborhodopsin (sensory rhodopsin II)
    M.Iwamoto, Y.Furutani, Y.Sudo, K.Shimono, H.Kandori, N.Kamo
    Biophys. J. 83 1130-1135 2002 Refereed
  • FTIR spectroscopy of the M photointermediate in pharaonis phoborhodopsin
    Y.Furutani, M.Iwamoto, K.Shimono, N.Kamo, H.Kandori
    Biophys. J. 83 3482-3489 2002 Refereed
  • Association between a photo-intermediate of a M-lacking mutant D75N of pharaonis phoborhodopsin and its cognate transducer
    Y.Sudo, M.Iwamoto, K.Shimono, N.Kamo
    J. Photochem. Photobiol. B 67 171-176 2002 Refereed
  • Tyr-199 and charged residues of pharaonis phoborhodopsin are important for the interaction with its transducer
    Y.Sudo, M.Iwamoto, K.Shimono, N.Kamo
    Biophys. J. 83 427-432 2002 Refereed
  • Association of pharaonis phoborhodopsin with its cognate transducer decreases the photo-dependent reactivity by water-soluble reagents of azide and hydroxylamine
    Y.Sudo, M.Iwamoto, K.Shimono, N.Kamo
    Biochim. Biophys. Acta 1558 63-69 2002 Refereed
  • Selective reaction of hydroxylamine with chromophore during the photocycle of pharaonis phoborhodopsin
    M.Iwamoto, Y.Sudo, K.Shimono, N.Kamo
    Biochim. Biophys. Acta 1514 152-158 2001 Refereed
  • Photochemistry and photoinduced proton-transfer by pharaonis phoborhodopsin
    N.Kamo, K.Shimono, M.Iwamoto, Y.Sudo
    Biochemistry (Mosc) 66 1277-1282 2001 Refereed
  • Environment around the chromophore in pharaonis phoborhodopsin: mutation analysis of the retinal binding site
    K.Shimono, Y.Ikeura, Y.Sudo, M.Iwamoto, N.Kamo
    Biochim. Biophys. Acta 1515 92-100 2001 Refereed
  • Pharaonis phoborhodopsin binds to its cognate truncated transducer even in the presence of a detergent with a 1 : 1 stoichiometry
    Y.Sudo, M.Iwamoto, K.Shimono, N.Kamo
    Photochem. Photobiol. 74 489-494 2001 Refereed
  • Structural changes of pharaonis phoborhodopsin upon photoisomerization of the retinal chromophore: Infrared spectral comparison with bacteriorhodopsin
    H.Kandori, K.Shimono, Y.Sudo, M.Iwamoto, Y.Shichida, N.Kamo
    Biochemistry 40 9238-9246 2001 Refereed
  • Photo-induced proton transport of pharaonis phoborhodopsin (sensory rhodopsin II) is ceased by association with the transducer
    Y.Sudo, M.Iwamoto, K.Shimono, M.Sumi, N.Kamo
    Biophys. J. 80 916-922 2001 Refereed
  • Involvement of two groups in reversal of the bathochromic shift of pharaonis phoborhodopsin by chloride at low pH
    K.Shimono, M.Kitami, M.Iwamoto, N.Kamo
    Biophys. Chem. 87 225-230 2000 Refereed
  • Effects of three characteristic amino acid residues of pharaonis phoborhodopsin on the absorption maximum
    K.Shimono, M.Iwamoto, M.Sumi, N.Kamo
    Photochem. Photobiol. 72 141-145 2000 Refereed
  • Light-induced proton uptake and release of pharaonis phoborhodopsin detected by a photoelectrochemical cell
    M.Iwamoto, K.Shimono, M.Sumi, K.Koyama, N.Kamo
    J. Phys. Chem. B 103 10311-10315 1999 Refereed
  • Positioning proton-donating residues to the Schiff-base accelerates the M-decay of pharaonis phoborhodopsin expressed in Escherichia coli
    M.Iwamoto, K.Shimono, M.Sumi, N.Kamo
    Biophys. Chem. 79 187-192 1999 Refereed
  • V108M mutant of pharaonis phoborhodopsin: Substitution caused no absorption change but affected its M-state
    K.Shimono, M.Iwamoto, M.Sumi, N.Kamo
     124 404-409 1998 Refereed
  • Functional expression of pharaonis phoborhodopsin in Escherichia coli
    K.Shimono, M.Iwamoto, M.Sumi, N.Kamo
    FEBS Lett. 420 54-56 1997 Refereed

Conference Activities & Talks

  • A tension-modulated modality of the KcsA channel exclusive for acid-activated state
    M. Iwamoto, S. Oiki
     Mar.  2019
  • Tension-mediated regulation of the KcsA channel: a novel dual modality of the channel activation
    M. Iwamoto, S. Oiki
    The 49th NIPS International Symposium Dec.  2018
  • Regulation of the activity of the KcsA potassium channel via bilayer tension-mediated sterol action
    M. Iwamoto, S.Oiki
     Sep.  2018
  • Membrane tension-assisted gating of the KcsA potassium channel revealed by the membrane sterol effects
    M. Iwamoto, S. Oiki
     Mar.  2018
  • Method for rapid perfusion of hydrophobic substances into lipid bilayer and its application for ion channel studies
    M. Iwamoto, S. Oiki
    Biophysical Society 62th Annual Meeting Feb.  2018
  • Specific and non-specific actions of membrane lipids on the gating of the potassium channel
    M. Iwamoto
     Sep.  2017
  • Effects of cholesterol on the function of the KcsA potassium channel
    M.Iwamoto, S.Oiki
     Mar.  2017
  • Rapid replacement of the lipid bilayer composition for the analysis of the lipid-effect on the ion channel function
    M.Iwamoto, S.Oiki
     Nov.  2016
  • Instantaneous change in lipid compositions in the bilayer membrane during current recordings using the contact bubble bilayer method
    M.Iwamoto, S.Oiki
     Mar.  2016
  • 液滴接触膜を応用したイオンチャネル機能解析法
    M.Iwamoto, S.Oiki
     Nov.  2015
  • The flux coupling between ion and water in the narrow pore of the K+ channels revealed by the streaming potential measurement
    M.Iwamoto, S.Oiki
     Sep.  2015
  • The formation of a contact bubble bilayer and its application to the functional analysis of ion channels
    M.Iwamoto, S.Oiki
     Sep.  2015
  • Methods for the functional analysis of ion channels on the contact bubble bilayer by the intra-bubble perfusion
    岩本 真幸, 老木 成稔
     Mar.  2015
  • Gating of the cytotoxic peptide polytheonamide B channel
    Y.Matsuki, M.Iwamoto, S.Matsunaga, S.Oiki
     Mar.  2015
  • Molecular mechanism of the membrane lipid-dependent gating of the KcsA potassium channel
    M.Iwamoto, S.Oiki
    The 45th NIPS International Symposium Nov.  2014
  • Development of the Diffracted X-ray Tracking Method for Recording the Single-Molecule Motions of Ion channel Proteins in a Sub-millisecond Time Resolution
    Hirofumi Shimizu, Masayuki Iwamoto, Yumiko Oota, Yoshikazu Hirai, Osamu Tabata, Shigetoshi Oiki
     Nov.  2014
  • 麻酔薬の細胞膜を介したカリウムチャネル制御機構の解明
    松木 悠佳, 三田 建一郎, 岩本 真幸, 重見 研司, 老木 成稔
     Sep.  2014
  • How do lipids regulate the gating activity of the channel protein? : Mechanism of a novel type of the lipid sensor
    岩本 真幸, 老木 成稔
     Sep.  2014
  • The Enhancement of Structural Fluctuations Prior to The Opening Conformational Changes of The KcsA Potassium Channel
    清水 啓史, 岩本真幸, 太田裕美子, 老木成稔
    The Biophysical Society of Japan Sep.  2014
  • Rectified protpn permeation through the hydrogen-bonded water-chain in a channel peptide
    Y.Matsuki, M.Iwamoto, S.Matsunaga, S.Oiki
     Sep.  2014
  • Modulation of the activation gating of the KcsA potassium channel by the membrane lipids
    M.Iwamoto, S.Oiki
     Apr.  2014
  • Effect of membrane lipids on the inactivation gating of the KcsA potassium channel
    岩本 真幸, 老木 成稔
     Mar.  2014
  • カリウムイオンチャネルKasAのゲート開閉と連動した膜中集合・離散挙動:原子間力顕微鏡による直接観察
    角野 歩, 山本 大輔, 岩本 真幸, 出羽 毅久, 老木 成稔
     Mar.  2014
  • ポリセオナミドBチャネルのプロトン透過:単一チャネル電流記録とプロトン透過モデル
    松木 悠佳, 岩本 真幸, 松永 茂樹, 老木 成稔
     Mar.  2014
  • Membrane lipids modulate the inactivation gating of the KcsA potassium channel
    M.Iwamoto, S.Oiki
    Biophysical Society 58th Annual Meeting Feb.  2014
  • Amphipathic antenna of an inward rectifier K+ channel responds to changes in the inner membrane leaflet
    岩本 真幸
     Aug.  2013
  • 心電図QT時間におけるKチャネルへのMgイオンの効果とその分子機構
    松木 悠佳, 三田 建一郎, 岩本 真幸, 重見 研司, 老木 成稔
     Jun.  2013
  • Proton permeation and pH-dependent gating of polytheonamide B
    松木 悠佳, 三田 建一郎, 炭竈 享司, 岩本 真幸, 清水 啓史, 老木 成稔
     Mar.  2013
  • The sensor for the inner membrane lipid modulating the activation gating of the KcsA potassium channel
    岩本 真幸, 老木 成稔
     Mar.  2013
  • The sensing sites for the membrane inner lipids regulate the activation gating of the KcsA potassium channel
    M.Iwamoto, S.Oiki
    Biophysical Society 57th Annual Meeting Feb.  2013
  • Rolling of N-terminal amphipathic helix on the anionic inner membrane leaflet stabilizes the open state of the KcsA potassium channel
    岩本 真幸, 老木 成稔
     Jan.  2013
  • カリウムイオンチャネルKasAのゲート開閉とリンクした脂質膜中での集合・離散ダイナミクス
    角野 歩, 山本 大輔, 炭竈 享司, 岩本 真幸, 出羽 毅久, 老木 成稔
     Jan.  2013
  • The Refinement of the Diffracted X-ray Tracking Method for Recording the Single-Molecule Motions of Proteins with Higher Time Resolution
    清水 啓史, 岩本真幸, 老木成稔
    The Biophysical Society of Japan Jan.  2013
  • MEMBRANE LIPID-SENSITIVE GATING OF THE KcsA POTASSIUM CHANNEL
    S.Oiki, M.Iwamoto
     Dec.  2012
  • カリウムチャネルモデルを用いた神経細胞へのカルシウムイオンの直接効果
    松木 悠佳, 三田 建一郎, 岩本 真幸, 老木 成稔, 髙倉 康, 重見 研司
     Sep.  2012
  • イオンチャネルのイオン選択性メカニズムの解明
    三田 建一郎, 岩本 真幸, 老木 成稔, 重見 研司
     Sep.  2012
  • カリウムチャネルの選択透過性とゲーティング
    老木 成稔, 岩本 真幸, 炭竈 享司, 清水 啓史
     Sep.  2012
  • KcsA カリウムチャネル活性に影響を及ぼすリン脂質作用部位の同定
    岩本 真幸, 老木 成稔
     Sep.  2012
  • KcsA カリウムイオンチャネルの溶液条件変化応答1 分子開閉ダイナミクスの解析
    清水 啓史, 岩本 真幸, A. Royant, D. Setten, L. Guerin, 青木 義満, M. Wulff, 老木 成稔
     Sep.  2012
  • Identification of the interaction site with the effective phospholipids for the KcsA potassium channel activity
    岩本 真幸, 老木 成稔
     Sep.  2012
  • Counting Ion and Water Molecules in a Streaming File through the Open-Filter Structure of the K Channel
    岩本 真幸
     Jul.  2012
  • 心電図QT時間へのマグネシウムイオンの直接効果ーカリウムチャネルモデルを用いてー
    松木 悠佳, 三田 建一郎, 岩本 真幸, 老木 成稔, 髙倉 康, 重見 研司
     Jun.  2012
  • サブミリ秒時間スケールでのKcsA カリウムイオンチャネル開閉構造変化の1 分子動画計測
    清水啓史, 岩本真幸, 今野卓, A. Royant, D. Setten, L. Guerin, M. Wulff, 老木 成稔
     Jun.  2012
  • Sidedness of the effective phospholipids on the function of the KcsA potassium channel revealed by the single-channel recording in the asymmetric lipid bilayer
    岩本 真幸, 老木 成稔
     Mar.  2012
  • 脂質二重膜組成がKcsAカリウムチャネル活性に及ぼす影響
    老木 成稔, 岩本 真幸
     Mar.  2012
  • The high entrance barrier for Li+ towards the open-filter of the KcsA potassium channel
    三田 建一郎, 岩本 真幸, 老木 成稔
     Mar.  2012
  • Development of diffracted X-ray tracking method for measuring gationg transitions of the KcsA potassium channeles in a sub-millisecound time resolution
    H.Shimizu, M.Iwamoto, T.Konno, A.Royant, V,D,Stetten, L.Guerin, M.Wolff, S.Oiki
     Mar.  2012
  • The asymmetric lipid bilayer revealed sidedness of the effective phospholipids on the single-channel properties of the KcsA potassium channel
    M.Iwamoto, S.Oiki
    Biophysical Society 56th Annual Meeting Feb.  2012
  • Laser-Triggered Single Molecular Gating Motions of the KcsA Potassium Channels Recorded in a Sub-Millisecond Time Resolution
    H.Shimizu, M.Iwamoto, T.Konno, A.Royant, S.Von,David, G.Laurent, M.Wulff, S.Oiki
     Feb.  2012
  • Envisioning the Ion Permeation Process through the KcsA Potassium Channel Using the Cycle Flux Algebra
    M.Iwamoto, S.Oiki
     Jan.  2012
  • 脂質二重膜組成がKcsAカリウムチャネル活性に及ぼす影響
    岩本 真幸, 老木 成稔
     Nov.  2011
  • KcsA チャネルのイオン選択制機構:フィルタ入口のLi+に対するバリア
    三田 建一郎, 岩本 真幸, 老木 成稔
     Nov.  2011
  • KcsA チャネルのpH依存性のマグネシウムイオンの効果
    松木 悠佳, 岩本 真幸, 清水 啓史, 老木 成稔
     Nov.  2011
  • イオンチャネルの透過を捉える:流れるイオンと水分子の配列を見る
    老木 成稔, 岩本 真幸, 炭竈 享司, 三田 建一郎
     Nov.  2011
  • イオンチャネル開閉構造変化の光トリガーX線1分子計測システムの開発
    清水 啓史, 岩本 真幸, 今野 卓, Royant A., von Stetten V.D., Guerin L., 老木 成稔, Wulff M.
     Nov.  2011
  • Effects of lipid bilayer components on the gating of the KcsA potassium channel
    岩本 真幸, 老木 成稔
     Sep.  2011
  • Tracking the Motions of Single Potassium Channels by Time resolved X-ray Diffraction
    H.Shimizu, M.Iwamoto, T.Konno, A.ROyant, D.Setten, L.Guerin, M.Wulff, S.Oiki
     Sep.  2011
  • Oriented reconstitution of a potassium channel KcsA in a giant unilamellar vesicle
    M.Yanagisawa, M.Iwamoto, A.Kato, K.Yoshikawa, S.Oiki
     Sep.  2011
  • Mechanism of Open Pore Selectivity of the KcsA Potassium Channel : Na+ trapping in the filter
    三田 建一郎, 岩本 真幸, 老木 成稔
     Sep.  2011
  • 新奇βへリックス型ペプチド・ポリセオナミドBのイオンチャネル活性
    岩本 真幸
     Dec.  2010
  • カリウムチャネルと揮発性麻酔薬の分子作用ー脂質平面膜法による実験系の確立をめざしてー
    松木 悠佳, 岩本 真幸, 三田 建一郎, 老木 成稔, 重見 研司
     Sep.  2010
  • A novel unusual peptide forms monovalent cation-selective pore through vectorial membrane insertion
    岩本 真幸, 清水 啓史, 村松 郁延, 松永 茂樹, 老木 成稔
     Sep.  2010
  • pH-dependent gating of KcsA potassium channel using an inactivation-free mutant, E71A
    松木 悠佳, 岩本 真幸, 清水 啓史, 老木 成稔
     May  2010
  • Properties for ion conduction and membrane insertion of a cytotoxic peptide from a marine sponge, polytheonamide B
    岩本 真幸, 清水 啓史, 村松 郁延, 松永 茂樹, 老木 成稔
     May  2010
  • pH-dependent gating of KcsA potassium channel using an inactivation-free mutant, E71A
    Y.Matsuki, M.Iwamoto, H.Shimizu, S.Oiki
     May  2010
  • エックス線1分子計測法によるイオンチャネル準安定状態の観測
    清水 啓史, 岩本 真幸
     May  2010
  • PH-DEPENDENT GATING OF KCSA POTASSIUM CHANNEL.
    Y.Matsuki, M.Iwamoto, H.Shimizu, S.Oiki
    54th Annumal Meeting The Biophysical Society Feb.  2010
  • A cytotoxic peptide from a marine sponge, polytheonamide B: I. Channel activity and vectorial insertion into the membrane
    M.Iwamoto, H.Shimizu, I.Muramatsu, S.Matsunaga, S.Oiki
     Feb.  2010
  • A cytotoxic peptide from a marine sponge, polytheonamide B: II. Properties for ion conduction and voltage dependent gating
    M.Iwamoto, H.Shimizu, I.Muramatsu, S.Matsunaga, S.Oiki
     Feb.  2010
  • 不活性化しない変異体であるE71Aを用いたKcsAカリウムチャネルのpH依存性
    松木 悠佳, 岩本 真幸, 清水 啓史, 老木 成稔
     Dec.  2009
  • Steady state distribution of ion and water in the open structure of KcsA potassium channel evaluated by the streaming potential
    岩本 真幸, 清水 啓史, 老木 成稔
     Nov.  2009
  • pH-dependent gating of KcsA potassium channel examined by using an inactivation-free" mutant E71A"
    Y.Matsuki, M.Iwamoto, H.Shimizu, S.Oiki
    The Biophysical Society of Japan Sep.  2009
  • KcsAカリウムチャネルのイオン透過過程を捉える実験的・論理的戦略
    老木 成稔, 岩本 真幸, 松木 悠佳, 清水 啓史
     Sep.  2009
  • Mechanism of ion permeation and gating of KcsA potassium channel : Overview and strategy
    老木 成稔, 清水 啓史, 岩本 真幸, 松木 悠佳, 今野 卓
    Molecular Science for Supra Functional Systems - Development pf Advanced Methods for Exploring Elementary Processes Aug.  2009
  • Current Status of Structural Dynamics Study in KcsA Potassium Channel
    清水 啓史, 岩本 真幸, 今野 卓, 老木 成稔
    Molecular Science for Supra Functional Systems - Development of Advanced Methods for Exploring Elementary Process Aug.  2009
  • Ion distribution in the open KcsA channel evaluated by the streaming potential
    M.Iwamoto, H.Shimizu, S.Oiki
     Jul.  2009
  • The water-ion coupling ratio for ion permeation through the KcsA potassium channel: Dependencies on concentration and species of permeating ions
    M.Iwamoto, H.Shimizu, S.Oiki
     Mar.  2009
  • Water-ion coupling in ion permeation through KcsA potassium channel revealed by streaming potential measurements
    岩本 真幸, 清水 啓史, 老木 成稔
     Dec.  2008
  • Temperature-dependence of Proton Permeation throngh a Voltage-Gated Proton Channel.
    M.Kuno, H.Ando, H.Morihata, H.Sakaki, H.Mori, H.Shimizu, M.Iwamoto, S.Oiki
     Dec.  2008
  • Visualisation of conformational changes of single KcsA potassium channels revealed global twisting motions upon gating.
    H.Shimizu, M.Iwamoto, T.Konno, A.Nihei, Y.C.Sasaki, S.Oiki
     Dec.  2008
  • KcsAカリウムチャネル開閉に伴うねじれ構造変化の1分子動画計測
    清水 啓史, 岩本 真幸, 今野 卓, 二瓶 亜三子, 佐々木 祐次, 老木 成稔
     Dec.  2008
  • Flux coupling between ion and water in the K+ selective pore
    M.Iwamoto, H.Shimizu, S.Oiki
     Mar.  2008
  • Water-ion coupling ratios for ion permeation through KcsA channel
    M.Iwamoto, H.Shimizu, S.Oiki
    Biophysical Society 52th Annual Meeting Feb.  2008
  • 表面プラズモン共鳴シグナルを利用したKcsAチャネル細胞質ドメインに関する研究
    岩本 真幸, 清水 啓史, 井上 史子, 今野 卓, 二瓶 亜三子, 佐々木 裕次, 老木 成稔
     Nov.  2005
  • Probing cytoplasmic domain of single KcsA channel by use of surface plasmon resonance signal and planar lipid bilayer
    M.Iwamoto, H.Shimizu, F.Inoue, T.Konno, Y.C.Sasaki, S.Oiki
     May  2005
  • Effect of gating and tetrabutylammonium (TBA) blocking on the surface structure of KcsA potassium channel
    M.Iwanoto, H.Shimizu, F.Inoue, T.Konno, Y.Sasaki, S.Oiki
    51th Biophysical Society Annual Meeting Mar.  2007
  • Single-molecular measurement of pH-sensitive gating dynamics of KcsA potassium channel by Diffracted X-ray Tracking (DXT)
    H.Shimizu, M.Iwanoto, F.Inoue, T.Konno, Y.Sasaki, S.Oiki
    51th Biophysical Society Annual Meeting Mar.  2007
  • Single channel molecules in motion: Global twisting of KcsA potassium channel upon gating
    Hirofumi Shimizu, Masayuki Iwamoto, Takashi Konno, Nihei Amiko, Yuji C. Sasaki, Shigetoshi Oiki
    Biology in Motion Jan.  2007
  • Changes in surface exposing sites of the KcsA potassium channel upon active gating: Effect of a channel blocker, tetrabutylammonium (TBA)
    M.Iwamoto, H.Shimizu, F.Inoue, T.Konnno, Y.Sasaki, S.Oiki
     Nov.  2006
  • Single-molecular gating dynamics of KcsA potassium channel measured by diffracted X-ray tracking
    H.Shimizu, M.Iwamoto, F.Inoue, T.Konnno, Y.Sasaki, S.Oiki
     Nov.  2006
  • KcsA チャネルのゲーティングによる構造変化
    老木 成稔, 清水 啓史, 岩本 真幸, 今野 卓, 佐々木 裕次
     Sep.  2006
  • Dynamic rearrangements of the surface structure of KcsA potassium channel evaluated by surface plasmon resonance signal
    M.Iwamoto, H.Shimizu, F.Inoue, T.Konnno, A.Nihei, Y.Sasaki, S.Oiki
     Sep.  2006
  • Conformational Changes in the cytoplasmic domain of KcsA potassium channel upon gating.
    岩本 真幸, 清水 啓史, 井上 史子, 今野 卓, 佐々木 裕次, 老木 成稔
     Mar.  2006
  • Surface Accessibility of the Cytoplasmic Domain of KcsA Channel Evaluated by Surface Plasmon Resonance Signal
    M.Iwamoto, H.Shimizu, F.Inoue, Y.Sasaki, S.Oiki
    50th Biophysical Society Annual Meeting Feb.  2006
  • Probing cytoplasmic domain of single KcsA channel by use of surface plasmon resonance signal and planar lipid bylayer
    H.Ando, M.Kuno, H.Shimizu, M.Iwamoto, S.Oiki
     Jan.  2005