TAKAHASHI Ichiro

FacultyApplied Chemistry and Biotechnology
Teacher OrganizationApplied Chemistry and Biotechnology
Education and
 Research Organization
Faculty of Engineering /Graduate School of Engineering
PositionAssociate Professor
Last Updated: 19/07/23 19:02

Researcher Profile & Settings

Name

    TAKAHASHI Ichiro

Affiliation

  •  Applied Chemistry and Biotechnology Associate Professor

Education

  • 1985The University of Tokyo 製薬化学
  • 1980The University of Tokyo

Academic & Professional Experience

  • Dec. 19861985-1986 Department of Chemistry, University of Florida(U.S.A)Post-doctoral Research Fellow 1986-1992 Faculty of Engineering, Fukui University, Research Assistant 1992-1995 Faculty of Engineering, Fukui University, Lecturer 1995-2007 Faculty of Engineering, Fukui University, Associate Professor

Overseas travel history

  • アメリカ合衆国 フロリダ大学化学科(Department ofn Chemistry, University of Florida) Mar.  2010- Mar. 2010
  • アメリカ合衆国 環太平洋国際化学会議 Dec.  2005- Dec. 2005

Research Activities

Published Papers

  • Exploration of Moderate Conditions and Substrate Variation in the Direct Condensation between Phthalide and Primary Amine Catalyzed by GaCl3. Are Aliphatic Amines less Reactive than Aromatic ones ?
    I.Takahashi, Y.Nishiwaki, K.Saitoh, T.Matsunaga, A.Aratake, T.Morita, and S.Hosoi,
    Heterocycles 99(1) 222-237 Apr.  2019 Refereed
  • Phthalimidine Synthesis via the Direct Condensation between Phthalide and Primary Amine in the Presence of Catalytic Amount of InCl3
    I.Takahashi, T.Matsunaga, Y.Izumi, Y.Sunada, N.Kawakami, Y.Horino, S.Inagaki, K.Saitoh, M.Hatanaka, S.Hosoi
    Letters in Organic Chemistry 14(3) 153-158 Apr.  2017 Refereed
    0
  • Application of the Mild-Condition Phthalimidine Synthesis with use of 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries. Effective Synthesis of Phthalimidines Possessing a variety of Substituents at 2-Position
    Heterocycles 93(2) 557-571 Apr.  2016 Refereed
  • Mechanistic Aspects of the Mild-Condition Phthalimidine Synthesis with use of 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries
    Heterocycles 93(2) 545-556 Apr.  2016 Refereed
  • Direct Modification of Tripeptides using Photoinduced Decarboxylative Radical Reactions
    K.Maeda, H.Saito, K.Okasa, K.Nishikawa, M.Sugie, T.Morita, I.Takahashi, Y.Yoshimi
    Tetrahedron 71 1117-1123 Jan.  2015 Refereed
  • Radical photocyclization route for macrocyclic lactone ring expansion and conversion to macrocyclic lactams and ketones
    K.Nishikawa, Y.Yoshimi, K.Maeda, T.Morita, I.Takahashi, T.Itou, S.Inagaki, M.Hatanaka
     78 582-589 Jan.  2013 Refereed
  • Induced circular Dichroism and Conformational Analysis of 2,2'-Binaphthyl Esters Derived from Primary Alcohols Possessing a Stereogenic Center in the beta-Position
    S.Hosoi, T.Tanaka, I.Takahashi, A.Sakushima, Y.Katsumoto
     6(2) 120-125 Mar.  2009 Refereed
  • Degradation of bisphenol A using sonochemical reactions
    M.Inoue, Y.Masuda, F.Okada, A.Sakurai, I.Takahashi, M.Sakakibara
     42 1379-1386 2008 Refereed
  • Purification and Properties of Diethyl p-Phthalate Esterase from Ochrobactrum anthoropi 6-2b
    S.Xu, C.Komatsu, I.Takahashi, S.Suye
    Sen-I Gakaki Shi 62(10) 226-231 Jan.  2006 Refereed
  • Circular dichroism in a chiral amide possessing an achiral binaphthyl chromophore
    S.Hosoi, J.Serata, A.Sakushima, F.Kiuchi, I.Takahashi, T.Ohta
    Letters in Organic Chemistry 3(1) 58-61 Jan.  2006 Refereed
  • Regression analysis in the characterization of hydrogen-bonded complex system involving 2-pyridone in terms of melting points before and after complexation
    I.Takahashi, M.Takahashi, H.Kitajima, M.Wagi, Y.Takahashi, M.Sabi, A.Hishida, M.Hatanaka, K.Isa, A.Yamano, A.Sakushima, S.Hosoi
    Heterocycles 66 195-199 Aug.  2005 Refereed
  • Reaction Systems Peripheral to the 1:2 Mannich Condensation Reaction between o-Phthalaldehyde and Primary Amine
    I.Takahashi, K.Nishiuchi, R.Miyamoto, M.Hatanaka, H.Uchida, K.Isa, A.Sakushima, S.Hosoi
     2(1) 40-43 Jan.  2005 Refereed
  • Studies of Isoindoles. 12. A Structural Revision of the 1:2 Mannich Type Condensation Reaction Product formed from o-Phthalaldehyde and Substituted Aniline
    I.Takahashi, R.Miyamoto, K.Nishiuchi, M.Hatanaka, A.Yamano, A.Sakushima, S.Hosoi
     63(6) 1267-1271 Jun.  2004 Refereed
  • Crystal Structure of 2,3-Bis(4-methoxycarbonylphenyl)naphthalene-1,4-dione
    I.Takahashi, M.Yamamoto, H.Kitajima, A.Sakushima, S.Hosoi
     20(4-6) x61-x62 Jun.  2004 Refereed
  • Crystal Structure of Diels-Alder Cycloadduct Formed from 1-(1,2,3-1H-Benzotriazol-1-yl)-2-(4-methylphenyl)-2H-isoindole and Dimethyl Acetylenedicarboxylate
    I.Takahashi, M.Tsuzuki, H.Kitajima, M.Hatanaka, S.Maeda, A.Yamano, T.Ohta, S.Hosoi
     19(6) 973-974 Jun.  2003 Refereed
  • Capture of Phenolic Endocrine Disruptors with 2-Pyridone
    I.Takahashi, M.Takahashi, H.Kitajima, M.Wagi, Y.Takahashi, M.Sabi, M.Hatanaka, A.Yamano, T.Ohta, S.Hosoi
     59(2) 517-520 Feb.  2003 Refereed
  • Crystal Structure of Dissymmetrically Trihydrated N,N’,N”-Tribenzoylmelamine (TBM)
    I.Takahashi, S.Kamimura, M.Hatanaka, H.Kitajima, A.Yamano, T.Ohta, S.Hosoi
     19(5) 807-808 May  2003 Refereed
  • Crystal Structure of a Complex between p-Nitrophenol and 2-Pyridone
    I.Takahashi, M.Takahashi, T.Morita, T.Keumi, H.Kitajima, M.Wagi, M.Hatanaka, T.Ohta, S.Hosoi
     18(5) 619-620 May  2002 Refereed
  • Annulation of 3-[(R)-p-Toluenesulfinyl]-2-oxoprorylidenetriphenylphosphorane with 1,4-Enediones; Highly Enantioselective Synthesis of Cyclopentenones
    Y.Shinohara, T.Kurata, H.Kitano, K.Mastumoto, I.Takahashi, S.Hosoi, T.Ohta, M.Hatanaka
    (8) 1245-1248 Aug.  2002 Refereed
  • Crystal Structure of a Complex formed from Triphenylphosphine Oxide and 6-Chloro-2-pyridone
    I.Takahashi, Y.Takahashi, M.Hatanaka, A.Yamano, T.Ohta, S.Hosoi
     18(12) 1407-1408 Dec.  2002 Refereed
  • Application of the Phthalimidine Synthesis with use of 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries. 2. Effective Synthesis of Phthalimidines Possessing Bulky Group at 2-Position
    I.Takahashi, T.Kawakami, M.Kimino, E.Hirano, S.Kamimura, T.Tamura, H.Kitajima, M.Hatanaka, H.Uchida, A.Nomura, M.Tanaka
     54(2) 635-638 Feb.  2001 Refereed
  • Studies on Water-Soluble Artificial Receptors Containing Chiral Side Chains derived from Carbohydrates. 2. Formation of Diastereomeric Inclusion Complexes between Optically Active Cyclophane TCP44 and Chiral Aromatic Guests in Acidic Aqueous Solutions
    I.Takahashi, Y.Aoyagi, I.Nakamura, A.Kitagawa, K.Matsumoto, H.Kitajima, K.Isa, K.Odashima, K.Koga
     51(6) 1371-1388 Jun.  1999 Refereed
  • Studies on the Water-soluble Artificial Receptors Containing Chiral Side Chains Derived from Carbohydrates - Syntheses of the Chiral Guest Compounds and the Preparation of Partially Optically-active Samples for Complexation Studies -
    I.Takahashi, Y.Aoyagi, I.Nakamura, A.Kitagawa, K.Matsumoto
     45(2) 319-337 1997 Not refereed
  • Studies on Water-Soluble Artificial Receptors Containing Chiral Side Chains Derived from Carbohydrates. 1. Synthesis of Optically Active Cyclophane TCP44 and Its Complexation Selectivity for Aromatic Guests in Acidic Aqueous Solutions
    I.Takahashi, Y.Hiyano, H.Arakawa, H.Kitajima, M.Hatanaka, K.Isa, K.Odashima, K.Koga
     46 589-603 1997 Refereed
  • Recent Progress of Phthalimidine Syntheses
    I.Takahashi, M.Hatanaka
     45(12) 2475-2499 Dec.  1997 Refereed
  • Preparation of 2-Substituted 1,3-Bis (benzotriazol-1-yl)isoindolines by the Double Mannich Condensation Reaction of o-Phthalaldehyde with Primary Amines in the Presence of 1,2,3-1H-Benzotriazole
    I.Takahashi, M.Tsuzuki, H.Yokota, T.Morita, H.Kitajima, K.Isa
     43(1) 71-90 Jan.  1996 Refereed
  • Substrate Properties of Adenosine- and Uridine-3'-phenylphosphonates for 3'-Nucleotidase/Nucleases
    H.Uchida, Y.-D.Wu, S.Sonoda, S.Fukushima, J.Fukuda, I.Takahashi, S.Maeda, A.Nomura
     15(1-3) 649-654 Mar.  1996 Refereed
  • Novel Phthalimidine Synthesis. Mannich Condensation of o-Phthalaldehyde with Primary Amines using 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries
    I.Takahashi, T.Kawakami, E.Hirano, H.Yokota, H.Kitajima
    (4) 353-355 Apr.  1996 Refereed
  • Studies on the Synthesis of Cleft Type Host Compound and Its Complex-Forming Ability with Hydrophobic Guest by means of 1H NMR Spectra
    I.Takahashi, K.Takeuchi, A.Yoshida, H.Kitajima
     9 53-56 1996 Not refereed
  • Studies on the Diamagnetic Effects. Part 2. Recalculation and Examination of the Induced Magnetic Field Distribution Patterns Nearby a Benzene Ring
    I.Takahashi
     44(2) 425-432 1996 Not refereed
  • Substrate Properties of Adenosine-and Uridine-3',5'-Bisphenylphosphonates for 3'-Nucleotidase/Nucleases
    H.Uchida, T.Oohara, H.Wada, I.Takahashi, A.Nomura
     15(10) 1561-1566 Oct.  1996 Refereed
  • Application of the Phthalimidine Synthesis with use of 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries. Part 1. A Simple Synthesis of (±)-Indoprofen
    I.Takahashi, E.Hirano, T.Kawakami, H.Kitajima
     43(11) 2343-2346 Nov.  1996 Refereed
  • Purification and Some Properties of Adenosine (Phosphate) Deaminase from the Liver of Squid Todarodes pacificus
    H.Uchida, Y.Narita, A.Matsuda, Y.Matsui, Y.-X.Chen, I.Takahashi, S.Maeda, A.Nomura
     59(7) 1276-1280 Jul.  1995 Refereed
  • Studies on the Diamagnetic Effects. Part 1. Approximate Calculation of Complete Elliptic Integrals based on a Modified Simpson Method Mediated by Limit Convergence Treatments
    I.Takahashi
     43(2) 241-252 1995 Not refereed
  • Ortho-Selective Side-Chain Nitration of Polymethylbenzophenones and Its Application to the Synthesis of Anthraquinones
    T.Mprita, K.Fujii, K.Taga, H.Tsukamoto, I.Takahashi, (late) T.Keumi, H.Kitajima
    (10) 809-815 Oct.  1995 Refereed
  • Visible Absorption Spectra of Aryl-p-Benzoquinones by Modified PPP MO Calculation
    Y.Inoue, K.Okumura, H.Kitajima, I.Takahashi, T.Morita, M.Matsuoka
     29(4) 345-354 1995 Refereed
  • Studies on the Meerwein Arylation-Based Preparation of 2, 3-Diaryl-benzene-1, 4-diones and Its Theoretical Interpretation
    I.Takahashi, O.Muramatsu, J.Fukuhara, Y.Hosokawa, N.Takeyama, T.Morita, H.Kitajima
    (3) 465-468 Mar.  1994 Refereed
  • Positional Reactivity of Acylpolymethylbenzenes in Electrophilic Substitution
    K.Matsuura, Y.Kimura, H.Takahashi, T.Morita, I.Takahashi, H.Kitajima, T.Keumi
     67(3) 757-765 Mar.  1994 Refereed
  • Studies on the Double Mannich Condensation Reaction of o-Phthalaldehyde with p-Substituted Anilines in the Presence of 1, 2, 3-1H-Benzotriazole
    I.Takahashi, M.Tsuzuki, H.Yokota, H.Kitajima, K.Isa
     37(2) 933-942 1994 Refereed
  • Linear Approximation Method to the Nuclear Magnetic Resonance (NMR)-based Titration Data of Inclusion Host-Guest Complexes. Part 3. Obtention of the Unified Dissociation Constant (Kd) Value to the Certain 1 : 1 Host-Guest Complex
    I.Takahashi, H.Kitajima
     42(1) 143-156 1994 Not refereed
  • A Stable Monosubstituted Isoindole Derivative : The Crystal Structure of 1-(1, 2, 3-1H-Benzotriazol-1-yl)-2-(4-methylphenyl)-2H-isoindole
    I.Takahashi, M.Tsuzuki, T.Keumi, H.Kitajima, K.Isa, S.Hosoi, Y.Tsuda
     42(4) 947-949 Apr.  1994 Refereed
  • Utility of an Inverse-Matrix Technique in the Fast Atom Bombardment Mass Spectrometry-based Structural Determination of 2-Substituted 1, 3-Bis(benzotriazolyl)isoindolines
    K.Isa, I.Takahashi, M.Tsuzuki, H.Yokota, H.Kitajima
    (12) 2403-2406 Dec.  1994 Refereed
  • Ortho-selective Side-chain Nitration of α-Bromoacylpolymethylbenzenes and its Application to the Syntheses of Indan-1-one and Inden-1-one Derivatives
    T.Keumi, K.Matsuura, N.Nakayama, T.Tsubita, T.Morita, I.Takahashi, H.Kitajima
     49(3) 537-556 1993 Refereed
  • Studies on the Diels-Alder Cycloaddition-based Syntheses of 6- and 7-(N, N-Dialkylamino)phenanthrene-1,4-diones
    I.Takahashi, J.Fukuhara, H.Nitta, H.Tomita, M.Tsuzuki, T.Matsui, H.Kitajima
     2 88-93 1993
  • MNDO calculation-based Examination on the Product Distribution in Meerwein Arylation of Naphthalene-1,4-diones
    I.Takahashi, N.Takeyama, T.Morita, H.Mori, M.Yamamoto, H.Nishimura, H.Kitajima
     8(5) 289-292 May  1993 Refereed
  • Studies on the Preparation of 2,3,5,6-Tetraarylbenzene-1,4-diones by means of Meerwein Arylation
    I.Takahashi, H.Nishimura, N.Takeyama, O.Muramatsu, J.Fukuhara, H.Kitajima
     8(8) 585-588 Aug.  1993 Refereed
  • The Solvent-dependent Product Distribution in the Condensation Reaction of o-Phthalaldehyde with p-Toluidine in the Presence of 1,2,3-1H-Benzotriazole
    I.Takahashi, M.Tsuzuki, H.Kitajima
     8(8) 589-592 Aug.  1993 Refereed
  • Application of a New Linear Approximation Method to the Nuclear Magnetic Resonance (NMR)-based Titration Data of Inclusion Host-Guest Complexes
    I.Takahashi, A.Nomura, H.Kitajima
     8(8) 593-596 Aug.  1993 Refereed
  • Studies on the Conformation of Arylated Benzene-1,4-diones in Solution based on Nuclear Magnetic Resonance Spectra
    I.Takahashi, J.Fukuhara, O.Muramatsu, H.Kitajima
     8(9) 725-728 Sep.  1993 Refereed
  • Dissociation of 1,2,3-1H-Benzotriazole from 1,3-Bis(1,2,3-1H-benzotriazol-1-yl)-2-(p-methylphenyl)isoindoline in Chloroform-d-
    I.Takahashi, H.Kitajima
     41(2) 265-271 1993 Not refereed
  • A New Strategy for the Evaluation of the Dissociation Constant (K-d-) of the Inclusion Host-Guest Complex, with Use of Nuclear Magnetic Resonance (NMR) Spectral Method
    I.Takahashi
     40(1) 7-22 1992 Not refereed
  • Utility of an Optically Active Paracyclophane as a New Type of Shift Reagent for Nuclear Magnetic Resonance (NMR) Spectra based on the Diastereomeric Host-Guest Complex Formation
    I.Takahashi, K.Odashima, K.Koga, H.Kitajima
     7(8) 653-656 Aug.  1992 Refereed
  • Nuclear Magnetic Resonance (NMR)-based Studies on N-Substituent Effects as to the Structural Modification of Chiral Host TCP44
    I.Takahashi, K.Odashima, K.Koga, H.Kitajima
     7(8) 657-660 Aug.  1992 Refereed
  • The Time-dependent Product Distribution in the Condensation Reaction of Phthalaldehyde with p-Toluidine in the Presence of 1,2,3-1H-Benzotriazole
    I.Takahashi, M.Tsuzuki, H.Kitajima
     7(9) 701-704 Sep.  1992 Refereed
  • Studies on the Products from the Condensation Reaction of 1,5-Dihydroxynaphthalene with Acetic Acid in the Presence of Lewis Acids
    I.Takahashi, T.Tanaka, H.Kitajima
     7(9) 705-708 Sep.  1992 Refereed
  • Studies on the Selective Preparation of 2-Aryl- and 2,3-Diarylnaphthalene-1,4-diones by means of Meerwein Arylation
    I.Takahashi, N.Takeyama, H.Mori, M.Yamamoto, H.Nishimura, H.Kitajima
     7(9) 709-712 Sep.  1992 Refereed
  • Studies on the Conformation of 2-Aryl- and 2,3-Diarylnaphthalene-1,4-diones in Solution based on Nuclear Magnetic Resonance (NMR) Spectra
    I.Takahashi, N.Takeyama, H.Nishimura, H.Mori, M.Yamamoto, H.Kitajima
     7(9) 713-716 Sep.  1992 Refereed
  • Diastereomeric Host-Guest Complex Formation between an Optically Active Paracyclophane having Quaternary Ammonium Groups and Chiral Aromatic Guests in aqueous solution
    I.Takahashi, K.Odashima, A.Miwa, K.Koga, H.Kitajima
     7(12) 913-916 Dec.  1992 Refereed
  • Utility of Acyloxypyridines and Acylazoles for the Lipase-catalyzed Enantioselective Acylation of 1-Phenylethanol
    T.Keumi, Y.Hiraoka, T.Ban, I.Takahashi, H.Kitajima
    (11) 1989-1992 Nov.  1991 Refereed
  • N-(1-(Benzotriazo1-1-yl)alkyl)amides, Versatile Amidoalkylation Reagents. Part 3. Syntheses of Open-Chain N-Protected-Hemithioaminals
    A.R.Katritzky, I.Takahashi, W.-Q.Fan, J.Pernak
    (12) 1147-1150 Dec.  1991 Refereed
  • A New Approach to the Synthetic Intermediates of Anthracyclinones via Sequential C-2--Symmetrical Naphthalene Derivatives
    I.Takahashi, A.Nomura, H.Kitajima
     20(10) 1569-1575 Oct.  1990 Refereed
  • The Synthesis of 1,2,3-Triazoles and Aziridines Using 2-(4-Pyridyl)ethyl Azide
    A.R.Katritzky, I.Takahashi, C.M.Marson, E.F.V.Scriven
     28(2) 149-155 1988 Refereed
  • Stereochemical Aspects of Asymmetric Diels-Alder Reaction Catalyzed by Chiral Alkoxyaluminum Dichlorides
    H.Takemura, N.Komeshima, I.Takahashi, S.Hashimoto, N.Ikota, K.Tomioka, K.Koga
     28(46) 5687-5690 1987 Refereed
  • 2-(4-Pyridyl)ethyl as a Protective Group for Sulfur Functionality
    A.R.Katritzky, I.Takahashi, C.M.Marson
     51(25) 4914-4920 1986 Refereed
  • Asymmetric Reduction of Arylglyoxylic Acids via Host-Guest Complex Formation with Optically Active Paracyclophanes
    I.Takahashi, K.Odashima, K.Koga
     33(8) 3571-3573 Aug.  1985 Refereed
  • Diastereomeric Host-Guest Complex Formation by an Optically Active Paracyclophane in Water
    I.Takahashi, K.Odashima, K.Koga
     25(9) 973-976 1984 Refereed
  • Studies on the Synthesis of 4-[1,8-Dioxygenated-9, 10-dioxoanthracen(or anthracen)-2-yl]-butanoic acid Derivatives
    I.Takahashi, S,Terashima
     30(12) 4539-4544 Dec.  1982 Refereed
  • Direct modification of tripeptides using photoinduced decarboxylative radical reactions
    Maeda, Kousuke;Saito, Hikaru;Osaka, Kazuyuki;Nishikawa, Keisuke;Sugie, Mai;Morita, Toshio;Takahashi, Ichiro;Yoshimi, Yasuharu
    TETRAHEDRON 71(7) 1117-1123 2015

Conference Activities & Talks

  • Direct condensation between phthalide and primary amine in the presence of literally catalytic amount of Lewis acid catalyst
    I.Takahashi, S.Hosoi
    Pacifichem 2015 Dec.  2015
  • 中員環ラクタムの合成および機能
    高橋 一朗
     Sep.  2012
  • Lewis acid-catalyzed direct condensation between phthalides and primary amines to give bioactive phthalimidines
    Ichiro Takahashi, Yusuke Horino, Yoshihiko Sugiura, Sho Inagaki, Kunihiko Shinooka, Minoru Hatanaka, Shinzo Hosoi
    Pacifichem 2010 Dec.  2010
  • Recent studies on the phthalimidine synthesis
    高橋 一朗
    FloHet 11 Mar.  2010

Educational Activities

Teaching Experience

  • Total synthesis of natural products
  • Organisms and Chemicals
  • Organic Chemistry I
  • Organic Chemistry Ⅱ
  • Bio-organic Chemistry
  • Society and Engineer
  • Seminar and Experiments for AppliedChemistry and Biotechnology Ⅰ
  • Seminar and Experiments for AppliedChemistry and Biotechnology Ⅱ
  • PBL of Applied Chemistry andBiotechnology
  • Advanced Organic Synthesis
  • Seminar for Organic Chemistry Ⅰ
  • Organisms and Chemicals
  • Organic Chemistry Ⅰ
  • Organic Chemistry I
  • Organic Chemistry Ⅱ
  • Bio-organic Chemistry
  • Society and Engineer
  • Experiments on Applied Chemistry andBiotechnology Ⅲ
  • Experiments on Applied Chemistry andBiotechnology Ⅲ
  • Seminar and Experiments for AppliedChemistry and Biotechnology Ⅰ
  • Seminar and Experiments for AppliedChemistry and Biotechnology Ⅱ
  • PBL of Applied Chemistry andBiotechnology
  • Advanced Organic Synthesis
  • Seminar for Organic Chemistry Ⅰ
  • Seminar for Organic Chemistry Ⅱ
  • Organisms and Chemicals
  • Organic Chemistry I
  • Total Synthesis of Natural Products