FacultyMorphological and Physiological Sciences, Anatomy
Teacher OrganizationMorphological and Physiological Sciences
Education and
 Research Organization
Faculty of Medical Sciences, School of Medicine
PositionAssociate Professor
Last Updated: 20/10/22 18:01

Researcher Profile & Settings


    HORIGUCHI Kazuhide


  •  Morphological and Physiological Sciences, Anatomy Associate Professor


  • 2000Waseda University 生命科学
  • 1995Waseda University Department of Basic Human Science

Academic & Professional Experience

  • Jan. 2011University of Fukui Faculty of Medical Sciences Senior Assistant Professor
  • Apr. 2004Dec. 2010University of Fukui Faculty of Medical Sciences Assistant Professor
  • 20022004Faculty of Agriculture, the University of Tokyo Researcher
  • 20002002University of Nevada, Reno, School of Medicine Postdoctoral fellow

Research Activities

Published Papers

  • Confocal and multiphoton calcium imaging of the enteric nervous system in anesthetized mice
    Motegi Y, Sato M, Horiguchi K, Ohkura M, Gengyo-Ando K, Ikegaya Y, Fusamae Y, Hongo Y, Suzuki M, Ogawa K, Takaki M, Nakai J
    Neurosci Res S0168-0102(18) 30523-6 Feb.  2019 Refereed
  • Disruption of the pacemaker activity of interstitial cells of Cajal vianitric oxide contributes to postoperative ileus.
    Kaji N, Nakayama S, Horiguchi K, Iino S, Ozaki H, Hori M
    Neurogastroenterol Motil May  2018 Refereed
  • DNA methylation, through DNMT1, has an essential role in the development of gastrointestinal smooth muscle cells and disease.
    Jorgensen BG, Berent RM, Ha SE, Horiguchi K, Sasse KC, Becker LS, Ro S
    Cell Death Dis 9(5) 474 Apr.  2018 Refereed
  • Expression and Function of the Cholinergic System in Immune Cells
    Front Immunol 8:1085 Sep.  2017 Refereed
  • Physiological functions of the cholinergic system in immune cells
    J Pharmacol Sci 134(1) 1-21 May  2017 Refereed
  • The anti-inflammatory pathway regulated via nicotinic acetylcholine receptors in rat intestinal mesothelial cells.
    J Vet Med Sci. 79(11) 1795-1802 Nov.  2017 Refereed
  • Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation
    N.Kaji,K.Horiguchi,S.Iino,S.Nakayama,T.Ohwada,Y.Otani, Firman,T.Murata,KM.Sanders,H.Ozaki,M.Hori
    Pharmacol Res 111 838-48 Sep.  2016 Refereed
  • Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells
    Islam MS, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, Ozaki H.
    Br J Pharmacol 173(16) 2532-42 Aug.  2016 Refereed
  • PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
    T.Nakamura,S.Maeda,K.Horiguchi,T.Maehara,K.Aritake,BI.Choi,Y.Iwakura,Y.Urade,T.Murata T.
    Nat Commun 6 7514-7514 Jul.  2015 Refereed
  • Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs
    Int Immunopharmacol 29(1) 127-34 Nov.  2015 Refereed
  • Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal
    T.Maehara, K.Matsumoto, K.Horiguchi, M.Kondo, S.Iino, S.Hiroe, T.Murata, H.Tubone, S.Shimada, H.Ozaki, M.Hori
     172(4) 1136-47 Feb.  2015 Refereed
  • Loss of serum response factor induces microRNA-mediated apoptosis in intestinal smooth muscle cells
    C.Park,MY.Lee,OJ.Slivano,PJ.Park,S.Ha,RT.Berent,R.Fuchs,NC.Collins,TJ.Yu,H.Syn,JK.Park,K.Horiguchi,JM.Miano, KM.Sanders,S.Ro.
    Cell Death Dis 6 :e2011 Dec.  2015 Refereed
  • SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity
    T.Fujii, K.Horiguchi, H.Sunaga, Y.Moriwaki, H.Misawa, T.Kasahara, S.Tsuji, K.Kawashima
    J Neuroimmunol 267(42006) 43-49 Feb.  2014 Refereed
  • PDGF and TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice
    MS.Islam, M.Kusakabe M, K.Horiguchi, S.Iino, T.Nakamura, K.Iwanaga, H.Hashimoto, S.Matsumoto, T.Murata, M.Hori, H.Ozaki
    Br J Pharmacol 171(2) 375-88 Jan.  2014 Refereed
  • Characterization of anoikis-resistant cells in mouse colonic epithelium
    H.Kawasaki, T.Yoshida, K.Horiguchi, T.Ohama, K.Sato
    J Vet Med Sci 75(9) 1173-1180 Apr.  2013 Refereed
  • Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function
    K.Kawashima, T.Fujii, Y.Moriwaki, H.Misawa, K.Horiguchi
    Ann N Y Acad Sci 1261 42202 Aug.  2012 Refereed
  • Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling
    O.Narumoto, Y.Matsuo, M.Sakaguchi, S.Shoji, N.Yamashita, D.Schubert, K.Abe, K.Horiguchi, T.Nagase, N.Yamashita
    Exp Mol Pathol. 19(93(1)) 18-25 Apr.  2012 Refereed
  • The role of CCR7 in allergic airway inflammation induced by house dust mite exposure
    O.Narumoto, Y.Matsuo, K.Horiguchi, M.Kawakami, S.Horiguchi, N.Yamashita, M.Sakaguchi, M.Lipp, N.Yamashita
    Cell Immunol. 275((1-2)) 24-32 Mar.  2012 Refereed
  • Mediatophore regulates acetylcholine release from T cells
    T.Fujii, Y.Takada-Takatori, K.Horiguchi, K.Kawashima
    J Neuroimmunol. 244((1-2)) 16-22 Mar.  2012 Refereed
  • Age-related changes in afferent responses in sensory neurons to mechanical stimulation of osteoblasts in coculture system
    K.Asada, K.Obata, K.Horiguchi, M.Takaki
    Am J Physiol Cell Physiol. 302(-5) C757-65 Mar.  2012 Refereed
  • iNOS expression in resident macrophages contributes to circulatory dysfunction of splanchnic vascular smooth muscle contractions in portal hypertensive rats
    M.Kajita, T.Murata, K.Horiguchi, M.Iizuka, M.Hori, H.Ozaki
    Am J Physiol Heart Circ Physiol 300(-3) H1021-31 Mar.  2011 Refereed
  • Interstitial cells of Cajal in the gastrointestinal musculature of W(jic) c-kit mutant mice
    S.Iino, S.Horiguchi, K.Horiguchi
    J Smooth Muscle Res 47((3-4):) 111-21 2011 Refereed
  • Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions
    O.Narumoto, K.Horiguchi, S.Horiguchi, Y.Moriwaki, H.Takano-Ohmuro, S.Shoji, H.Misawa, N.Yamashita, T.Nagase, K.Kawashima, N.Yamashita
    Biochem Biophys Res Commun. 398(-4) 713-8 Aug.  2010 Refereed
  • Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice
    S.Horiguchi, K.Horiguchi, Y.Nojyo, S.Iino
    Biochem Biophys Res Commun. 396(-3) 774-9 Jun.  2010 Refereed
  • Delayed gastric emptying and disruption of the interstitial cells of Cajal network after gastric ischaemia and reperfusion
    S.Suzuki, H.Suzuki, K.Horiguchi, H.Tsugawa, J.Matsuzaki, T.Takagi, N.Shimojima, T.Hibi
     22(-5) 585-e126 May  2010 Refereed
  • Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells
    K.Horiguchi, S.Horiguchi, N.Yamashita, K.Irie, J.Masuda, H.Takano-Ohmuro, T.Himi, M.Miyazawa, Y.Moriwaki, T.Okuda, H.Misawa, H.Ozaki, K.Kawashima
     87(12) 306987 Aug.  2009 Refereed
  • Wsh/Wsh c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine
    S.Iino, K.Horiguchi, Y.Nojyo
    Neurosci.Lett 459 123-126 Jul.  2009 Refereed
  • c-Kit-negative fibroblast-like cells express platelet-derived growth factor receptor α in the murine gastrointestinal musculature
    S.Iino, K.Horiguchi, S.Horiguchi, Y.Nojyo
    Histochem.Cell Biol 131 691-702 Jun.  2009 Refereed
  • Interstitial cells of Cajal contain signaling molecules for transduction of nitrergic stimulation in guinea pig caecum
    S.Iino, K.Horiguchi, Y.Nojyo, Ward SM, Sanders KM
    Neurogastroenterol.Motil 21 542-e13 Feb.  2009 Refereed
  • Interstitial cells of Cajal are innervated by nitrergic nerves and express nitric oxide-sensitive guanylate cyclase in the guinea-pig gastrointestinal tract
    S.Iino, K.Horiguchi, Y.Nojyo
    (152) 437-448 Mar.  2008 Refereed
  • MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation
    M.Hori, H.Nobe, K.Horiguchi, H.Ozaki
     294(-2) C391-401 Feb.  2008 Refereed
  • Interstitial cells of Cajal in the gastrointestinal musculature of W mutant mice
    S.Iino, S.Horiguchi, K.Horiguchi, Y.Nojyo
     70 163-173 Jan.  2007 Refereed
  • Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis
    K.Kinoshita, K.Horiguchi, M.Fujisawa, F.Kobirumaki, S.Yamato, M.Hori, H.Ozaki
     127 41-53 2007 Refereed
  • Immunocytochemical identification of interstitial cells of Cajal in the murine fundus using a live-labelling technique
    CJ.Stratton, SM.Ward, K.Horiguchi, KM.Sanders
     19 152-9 2007 Refereed
  • Inhibition of gut pacemaker cell formation from mouse ES cells by the c-kit inhibitor
    M.Takaki, H.Misawa, J.Shimizu, H.Kuniyasu, K.Horiguchi
     359 354-359 2007 Refereed
  • Interstitial cells of Cajal involved in neurotransmission in the gastrointestinal tract
    S.Iino, K.Horiguchi
     39 145-153 2006 Refereed
  • c-Kit-stem cell factor signal-independent development of interstitial cells of Cajal in murine small intestine
    Iino S, Horiguchi K, Horiguchi S.
    Cell Tissue Res Nov.  2019 Refereed

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