FacultyMorphological and Physiological Sciences, Anatomy
Teacher OrganizationMorphological and Physiological Sciences
Education and
 Research Organization
Faculty of Medical Sciences, School of Medicine
PositionAssociate Professor
Last Updated: 18/12/04 09:13

Researcher Profile & Settings


    HORIGUCHI Kazuhide


  •  Morphological and Physiological Sciences, Anatomy Associate Professor


  • 2000Waseda University 生命科学
  • 1995Waseda University Department of Basic Human Science

Academic & Professional Experience

  • Jan. 2011University of Fukui Faculty of Medical Sciences Senior Assistant Professor
  • Apr. 2004Dec. 2010University of Fukui Faculty of Medical Sciences Assistant Professor
  • 20022004Faculty of Agriculture, the University of Tokyo Researcher
  • 20002002University of Nevada, Reno, School of Medicine Postdoctoral fellow

Research Activities

Published Papers

  • Expression and Function of the Cholinergic System in Immune Cells
    Front Immunol 8:1085 Sep.  2017 Refereed
  • Physiological functions of the cholinergic system in immune cells
    J Pharmacol Sci 134(1) 1-21 May  2017 Refereed
  • The anti-inflammatory pathway regulated via nicotinic acetylcholine receptors in rat intestinal mesothelial cells.
    J Vet Med Sci. 79(11) 1795-1802 Nov.  2017 Refereed
  • Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation
    N.Kaji,K.Horiguchi,S.Iino,S.Nakayama,T.Ohwada,Y.Otani, Firman,T.Murata,KM.Sanders,H.Ozaki,M.Hori
    Pharmacol Res 111 838-48 Sep.  2016 Refereed
  • Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells
    Islam MS, Horiguchi K, Iino S, Kaji N, Mikawa S, Hori M, Ozaki H.
    Br J Pharmacol 173(16) 2532-42 Aug.  2016 Refereed
  • PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
    T.Nakamura,S.Maeda,K.Horiguchi,T.Maehara,K.Aritake,BI.Choi,Y.Iwakura,Y.Urade,T.Murata T.
    Nat Commun 6 7514-7514 Jul.  2015 Refereed
  • Non-neuronal cholinergic system in regulation of immune function with a focus on α7 nAChRs
    Int Immunopharmacol 29(1) 127-34 Nov.  2015 Refereed
  • Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal
    T.Maehara, K.Matsumoto, K.Horiguchi, M.Kondo, S.Iino, S.Hiroe, T.Murata, H.Tubone, S.Shimada, H.Ozaki, M.Hori
     172(4) 1136-47 Feb.  2015 Refereed
  • Loss of serum response factor induces microRNA-mediated apoptosis in intestinal smooth muscle cells
    C.Park,MY.Lee,OJ.Slivano,PJ.Park,S.Ha,RT.Berent,R.Fuchs,NC.Collins,TJ.Yu,H.Syn,JK.Park,K.Horiguchi,JM.Miano, KM.Sanders,S.Ro.
    Cell Death Dis 6 :e2011 Dec.  2015 Refereed
  • SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205+ dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity
    T.Fujii, K.Horiguchi, H.Sunaga, Y.Moriwaki, H.Misawa, T.Kasahara, S.Tsuji, K.Kawashima
    J Neuroimmunol 267(42006) 43-49 Feb.  2014 Refereed
  • PDGF and TGF-β promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice
    MS.Islam, M.Kusakabe M, K.Horiguchi, S.Iino, T.Nakamura, K.Iwanaga, H.Hashimoto, S.Matsumoto, T.Murata, M.Hori, H.Ozaki
    Br J Pharmacol 171(2) 375-88 Jan.  2014 Refereed
  • Characterization of anoikis-resistant cells in mouse colonic epithelium
    H.Kawasaki, T.Yoshida, K.Horiguchi, T.Ohama, K.Sato
    J Vet Med Sci 75(9) 1173-1180 Apr.  2013 Refereed
  • Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function
    K.Kawashima, T.Fujii, Y.Moriwaki, H.Misawa, K.Horiguchi
    Ann N Y Acad Sci 1261 42202 Aug.  2012 Refereed
  • Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling
    O.Narumoto, Y.Matsuo, M.Sakaguchi, S.Shoji, N.Yamashita, D.Schubert, K.Abe, K.Horiguchi, T.Nagase, N.Yamashita
    Exp Mol Pathol. 19(93(1)) 18-25 Apr.  2012 Refereed
  • The role of CCR7 in allergic airway inflammation induced by house dust mite exposure
    O.Narumoto, Y.Matsuo, K.Horiguchi, M.Kawakami, S.Horiguchi, N.Yamashita, M.Sakaguchi, M.Lipp, N.Yamashita
    Cell Immunol. 275((1-2)) 24-32 Mar.  2012 Refereed
  • Mediatophore regulates acetylcholine release from T cells
    T.Fujii, Y.Takada-Takatori, K.Horiguchi, K.Kawashima
    J Neuroimmunol. 244((1-2)) 16-22 Mar.  2012 Refereed
  • Age-related changes in afferent responses in sensory neurons to mechanical stimulation of osteoblasts in coculture system
    K.Asada, K.Obata, K.Horiguchi, M.Takaki
    Am J Physiol Cell Physiol. 302(-5) C757-65 Mar.  2012 Refereed
  • iNOS expression in resident macrophages contributes to circulatory dysfunction of splanchnic vascular smooth muscle contractions in portal hypertensive rats
    M.Kajita, T.Murata, K.Horiguchi, M.Iizuka, M.Hori, H.Ozaki
    Am J Physiol Heart Circ Physiol 300(-3) H1021-31 Mar.  2011 Refereed
  • Interstitial cells of Cajal in the gastrointestinal musculature of W(jic) c-kit mutant mice
    S.Iino, S.Horiguchi, K.Horiguchi
    J Smooth Muscle Res 47((3-4):) 111-21 2011 Refereed
  • Down-regulation of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1), an endogenous allosteric alpha7 nicotinic acetylcholine receptor modulator, in murine and human asthmatic conditions
    O.Narumoto, K.Horiguchi, S.Horiguchi, Y.Moriwaki, H.Takano-Ohmuro, S.Shoji, H.Misawa, N.Yamashita, T.Nagase, K.Kawashima, N.Yamashita
    Biochem Biophys Res Commun. 398(-4) 713-8 Aug.  2010 Refereed
  • Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice
    S.Horiguchi, K.Horiguchi, Y.Nojyo, S.Iino
    Biochem Biophys Res Commun. 396(-3) 774-9 Jun.  2010 Refereed
  • Delayed gastric emptying and disruption of the interstitial cells of Cajal network after gastric ischaemia and reperfusion
    S.Suzuki, H.Suzuki, K.Horiguchi, H.Tsugawa, J.Matsuzaki, T.Takagi, N.Shimojima, T.Hibi
     22(-5) 585-e126 May  2010 Refereed
  • Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells
    K.Horiguchi, S.Horiguchi, N.Yamashita, K.Irie, J.Masuda, H.Takano-Ohmuro, T.Himi, M.Miyazawa, Y.Moriwaki, T.Okuda, H.Misawa, H.Ozaki, K.Kawashima
     87(12) 306987 Aug.  2009 Refereed
  • Wsh/Wsh c-Kit mutant mice possess interstitial cells of Cajal in the deep muscular plexus layer of the small intestine
    S.Iino, K.Horiguchi, Y.Nojyo
    Neurosci.Lett 459 123-126 Jul.  2009 Refereed
  • c-Kit-negative fibroblast-like cells express platelet-derived growth factor receptor α in the murine gastrointestinal musculature
    S.Iino, K.Horiguchi, S.Horiguchi, Y.Nojyo
    Histochem.Cell Biol 131 691-702 Jun.  2009 Refereed
  • Interstitial cells of Cajal contain signaling molecules for transduction of nitrergic stimulation in guinea pig caecum
    S.Iino, K.Horiguchi, Y.Nojyo, Ward SM, Sanders KM
    Neurogastroenterol.Motil 21 542-e13 Feb.  2009 Refereed
  • Interstitial cells of Cajal are innervated by nitrergic nerves and express nitric oxide-sensitive guanylate cyclase in the guinea-pig gastrointestinal tract
    S.Iino, K.Horiguchi, Y.Nojyo
    (152) 437-448 Mar.  2008 Refereed
  • MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation
    M.Hori, H.Nobe, K.Horiguchi, H.Ozaki
     294(-2) C391-401 Feb.  2008 Refereed
  • Interstitial cells of Cajal in the gastrointestinal musculature of W mutant mice
    S.Iino, S.Horiguchi, K.Horiguchi, Y.Nojyo
     70 163-173 Jan.  2007 Refereed
  • Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis
    K.Kinoshita, K.Horiguchi, M.Fujisawa, F.Kobirumaki, S.Yamato, M.Hori, H.Ozaki
     127 41-53 2007 Refereed
  • Immunocytochemical identification of interstitial cells of Cajal in the murine fundus using a live-labelling technique
    CJ.Stratton, SM.Ward, K.Horiguchi, KM.Sanders
     19 152-9 2007 Refereed
  • Inhibition of gut pacemaker cell formation from mouse ES cells by the c-kit inhibitor
    M.Takaki, H.Misawa, J.Shimizu, H.Kuniyasu, K.Horiguchi
     359 354-359 2007 Refereed
  • Interstitial cells of Cajal involved in neurotransmission in the gastrointestinal tract
    S.Iino, K.Horiguchi
     39 145-153 2006 Refereed