KOSAKA Nobuyuki

FacultyRadiology and Laboratory Medicine, Radiology
Teacher OrganizationRadiology and Laboratory Medicine
Education and
 Research Organization
Faculty of Medical Sciences, School of Medicine
PositionAssociate Professor
Last Updated: 19/11/01 20:26

Researcher Profile & Settings

Name

    KOSAKA Nobuyuki

Affiliation

  •  Radiology and Laboratory Medicine, Radiology Associate Professor

Research Activities

Published Papers

  • Fat-subtracted three-dimensional time-of-flight MR angiography of the neck by use of fat-only images with the two-point Dixon technigue
    Y Fujiwara, Y Ishimori, I Yamaguchi, N Kosaka, H Kimura, T Adachi
    Radiological Physics and Technology 8(2) 193-199 Jul.  2015 Refereed
  • Serial changes of (18)F-FDG PET/CT findings in ischiopubic synchondrosis: comparison with contrast-enhanced MRI
    Kazunobu Tsuji, Tatsuro Tsuchida, Nobuyuki Kosaka, Akihiko Tanizawa, Kimura Hirohiko
    Hell J Nucl Med. 18(1) 66-67 Mar.  2015 Refereed
  • Arterial spin labeling perfusion-weighted MRI for long-term follow-up of a cerebral arteriovenous malformation after stereotactic radiosurgery
    Kazuhiro Shimizu, Nobuyuki Kosaka, Tatsuya Yamamoto, Hiroki Shioura, Toshiaki Kodera, Ken-ichiro Kikuta, Hirohiko Kimura
    Acta Radiologica Short Reports 3(1) 2.05E+15 Jan.  2014 Refereed
  • A rare congenital anomaly, bridge-like appendiceal fistula to the terminal ileum, demonstrated by MDCT
    Takeuchi K, Kosaka N, Kinoshita K, Sakai T, Sawai K, Imamura Y, Kimura H
    Surgical and radiologic anatomy 35(6) 523-527 Aug.  2013 Refereed
  • Utility of high-resolution computed tomography for predicting risk of sputum smear-negative pulmonary tuberculosis
    M.Nakanishi, Y.Demura, S.Ameshima, N.Kosaka, Y.Chiba, S.Nishikawa, H.Itoh, T.Ishizaki
     22 Jan.  2009 Refereed
  • 18F-FDG PET of common enhancing malignant brain tumors
    N.Kosaka, T.Tsuchida, H. Uematsu, H.Kimura, H.Okazawa, H.Itoh
    Am J Roentgenol 190(6) W365-W369 Jun.  2008 Refereed
  • Imaging by multiple modalities of patients with a carotidynia syndrome
    Nobuyuki Kosaka, Tadashi Sagoh, Hidemasa Uematsu, Hirohiko Kimura, Shiro Miyayama, Masato Noguchi, Harumi Itoh
    European Radiology 17(9) 2007 Sep.  2007 Refereed
  • Utility of multi-detector CT for pre-operative diagnosis of internal hernia through a defect in the broad ligament
    Nobuyuki Kosaka, Hidemasa Uematsu, Hirohiko Kimura, Sanae Yamamori, Katsuyasu Hirano, Harumi Itoh
    European Radiology 17(4) 1130-1133 Apr.  2007 Refereed
  • Standardized uptake value differences between primary and metastatic lesions in F-18-FDG PET/CT of patients with lung cancer
    Kosaka, Nobuyuki;Tsuchida, Tatsuro;Tsuji, Kazunobu;Shimizu, Kazuhiro;Kimura, Hirohiko
    ACTA RADIOLOGICA 56(11) 1329-1335 Nov.  2015
  • Comparison of long-labeled pseudo-continuous arterial spin labeling (ASL) features between young and elderly adults: special reference to parameter selection
    Fujiwara, Yasuhiro;Matsuda, Tsuyoshi;Kanamoto, Masayuki;Tsuchida, Tatsuro;Tsuji, Kazunobu;Kosaka, Nobuyuki;Adachi, Toshiki;Kimura, Hirohiko
    ACTA RADIOLOGICA 58(1) 84-90 Jan.  2017
  • Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging
    Shimizu, Kazuhiro;Kosaka, Nobuyuki;Fujiwara, Yasuhiro;Matsuda, Tsuyoshi;Yamamoto, Tatsuya;Tsuchida, Tatsuro;Tsuchiyama, Katsuki;Oyama, Nobuyuki;Kimura, Hirohiko
    MAGNETIC RESONANCE IN MEDICAL SCIENCES 16(1) 38-44 2017
    Purpose: The importance of arterial transit time (ATT) correction for arterial spin labeling MRI has been well debated in neuroimaging, but it has not been well evaluated in renal imaging. The purpose of this study was to evaluate the feasibility of pulsed continuous arterial spin labeling (pcASL) MRI with multiple post-labeling delay (PLD) acquisition for measuring ATT-corrected renal blood flow (ATC-RBF).
    Materials and Methods: A total of 14 volunteers were categorized into younger (n = 8; mean age, 27.0 years) and older groups (n = 6; 64.8 years). Images of pcASL were obtained at three different PLDs (0.5, 1.0, and 1.5 s), and ATC-RBF and ATT were calculated using a single-compartment model. To validate ATC-RBF, a comparative study of effective renal plasma flow (ERPF) measured by 99mTc-MAG3 scintigraphy was performed. ATC-RBF was corrected by kidney volume (ATC-cRBF) for comparison with ERPF.
    Results: The younger group showed significantly higher ATC-RBF (157.68 ± 38.37 mL/min/100 g) and shorter ATT (961.33 ± 260.87 ms) than the older group (117.42 ± 24.03 mL/min/100 g and 1227.94 ± 226.51 ms, respectively; P < 0.05). A significant correlation was evident between ATC-cRBF and ERPF (P < 0.05, r = 0.47). With suboptimal single PLD (1.5 s) settings, there was no significant correlation between ERPF and kidney volume-corrected RBF calculated from single PLD data.
    Conclusion: Calculation of ATT and ATC-RBF by pcASL with multiple PLD was feasible in healthy volunteers, and differences in ATT and ATC-RBF were seen between the younger and older groups. Although ATT correction by multiple PLD acquisitions may not always be necessary for RBF quantification in the healthy subjects, the effect of ATT should be taken into account in renal ASL–MRI as debated in brain imaging.
  • Development of an Magnetic Resonance Imaging Safety Management System for Metallic Biomedical Products Using an Magnetic Resonance Compatibility Database and Inquiry-based Patient Records
    Fujiwara Yasuhiro;Kata Tomomi;Fujimoto Shinichi;Yachida Takuya;Kanamoto Masayuki;Nanbu Yousuke;Seki Kouichirou;Kosaka Nobuyuki;Kimura Hirohiko;Adachi Toshiki
    Jpn. J. Radiol. Technol. 70(12) 1413-1419 2014
    Several incidents involving magnetic resonance imaging (MRI) examinations of patients with unchecked MR-unsafe metallic products have been reported. To improve patient safety, we developed a new MRI safety management system for metallic biomedical products and evaluated its efficiency in clinical practice. Our system was integrated into the picture archiving and communication system (PACS) and comprised an MR compatibility database and inquiry-based patient records of internal metallic biomedical products, enabling hospital staff to check MR compatibility by product name. A total of 6,637 biomedical implants and devices were listed in this system, including product names and their MR compatibilities. Furthermore, MRI histories for each patient at our hospital were also recorded. Using this system, it was possible to confirm the MR compatibility of the patients' metallic biomedical products effectively and to reduce the number of unchecked internal products through systematic patient inquiry. In conclusion, our new system enhanced metallic biomedical product checking procedures, and improved patient safety during clinical MRI examinations.
  • Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging
    SHIMIZU Kazuhiro;KOSAKA Nobuyuki;FUJIWARA Yasuhiro;MATSUDA Tsuyoshi;YAMAMOTO Tatsuya;TSUCHIDA Tatsuro;TSUCHIYAMA Katsuki;OYAMA Nobuyuki;KIMURA Hirohiko
    Magnetic Resonance in Medical Sciences 0 2016
    Purpose: The importance of arterial transit time (ATT) correction for arterial spin labeling MRI has been well debated in neuroimaging, but it has not been well evaluated in renal imaging. The purpose of this study was to evaluate the feasibility of pulsed continuous arterial spin labeling (pcASL) MRI with multiple post-labeling delay (PLD) acquisition for measuring ATT-corrected renal blood flow (ATC-RBF).Materials and Methods: A total of 14 volunteers were categorized into younger (n = 8; mean age, 27.0 years) and older groups (n = 6; 64.8 years). Images of pcASL were obtained at three different PLDs (0.5, 1.0, and 1.5 s), and ATC-RBF and ATT were calculated using a single-compartment model. To validate ATC-RBF, a comparative study of effective renal plasma flow (ERPF) measured by 99mTc-MAG3 scintigraphy was performed. ATC-RBF was corrected by kidney volume (ATC-cRBF) for comparison with ERPF.Results: The younger group showed significantly higher ATC-RBF (157.68 ± 38.37 mL/min/100 g) and shorter ATT (961.33 ± 260.87 ms) than the older group (117.42 ± 24.03 mL/min/100 g and 1227.94 ± 226.51 ms, respectively; P < 0.05). A significant correlation was evident between ATC-cRBF and ERPF (P < 0.05, r = 0.47). With suboptimal single PLD (1.5 s) settings, there was no significant correlation between ERPF and kidney volume-corrected RBF calculated from single PLD data.Conclusion: Calculation of ATT and ATC-RBF by pcASL with multiple PLD was feasible in healthy volunteers, and differences in ATT and ATC-RBF were seen between the younger and older groups. Although ATT correction by multiple PLD acquisitions may not always be necessary for RBF quantification in the healthy subjects, the effect of ATT should be taken into account in renal ASL窶溺RI as debated in brain imaging.
  • Simultaneous acquisition of high-contrast and quantitative liver T1 images using 3D phase-sensitive inversion recovery: a feasibility study.
    Fujiwara Yasuhiro;Maruyama Hirotoshi;Kosaka Nobuyuki;Ishimori Yoshiyuki
    Acta radiologica (Stockholm, Sweden : 1987) 2016
    BACKGROUND:Tumor-to-liver contrast is low in images of chronically diseased livers because gadolinium-based hepatocyte-specific contrast agents (Gd-EOB-DTPA) accumulate less to hepatocytes.;PURPOSE:To determine whether phase-sensitive inversion recovery (PSIR) could improve the T1 contrasts of Gd-based contrast agents and liver parenchyma and simultaneously provide accurate T1 values for abdominal organs.;MATERIAL AND METHODS:The image contrasts of phantoms with different Gd concentrations that were obtained using PSIR were compared to conventional turbo field echo (TFE) results. T1 value was estimated using PSIR by performing iterations to investigate the two IR magnetization evolutions. The estimated T1 values were validated using IR-spin echo (IR-SE) and Look-Locker (L-L) sequences. In an inツ黴€vivo study, the liver-to-spleen and liver-to-muscle contrasts of the PSIR and TFE images of seven volunteers were compared, as were the T1 values of liver parenchyma, spleen, and muscle obtained using PSIR and L-L sequences.;RESULTS:The PSIR images showed T1 contrasts higher than those in the TFE results. The PSIR and IR-SE T1 values were linearly correlated. Additionally, the R1 estimated using PSIR were correlated with those measured using IR-SE and L-L. In the inツ黴€vivo study, the liver-to-spleen and liver-to-muscle contrasts of PSIR were significantly higher than those obtained using TFE. T1 values of abdominal organs obtained using PSIR and L-L were clearly correlated.;CONCLUSION:PSIR may be capable of improving liver image T1 contrasts when Gd-based contrast agents are employed and simultaneously yielding accurate T1 values of abdominal organs.
  • Sensitive β-Galactosidase-Targeting Fluorescence Probe for Visualizing Small Peritoneal Metastatic Tumors In Vivo
    Asanuma D, Sakabe M, Kamiya M, Yamamoto K, Hiratake J, Ogawa M, Kosaka N, Choyke PL, Nagano T, Kobayashi H, Urano Y.
     6 6463-6463 Mar.  2015 Refereed
  • Comparison of long-labeled pseudo-continuous arterial spin labeling (ASL) features between young and elderly adults: special reference to parameter selection.
    Y Fujiwara, T Matsuda, M Kanamoto, T Tsuchida, K Tsuji, N Kosaka, T Adachi, H Kimura
    Acta Radiol 58(1) 84-90 Jan.  2017 Refereed
  • Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging
    K Shimizu, N Kosaka, Y Fujiwara, T Matsuda,T Yamamoto, T Tsuchida, K Tsuchiyama, N Oyama, H Kimura
    Magn Reson Med Sci 16(1) 38-44 Jan.  2017 Refereed
    Purpose: The importance of arterial transit time (ATT) correction for arterial spin labeling MRI has been well debated in neuroimaging, but it has not been well evaluated in renal imaging. The purpose of this study was to evaluate the feasibility of pulsed continuous arterial spin labeling (pcASL) MRI with multiple post-labeling delay (PLD) acquisition for measuring ATT-corrected renal blood flow (ATC-RBF).Materials and Methods: A total of 14 volunteers were categorized into younger (n = 8; mean age, 27.0 years) and older groups (n = 6; 64.8 years). Images of pcASL were obtained at three different PLDs (0.5, 1.0, and 1.5 s), and ATC-RBF and ATT were calculated using a single-compartment model. To validate ATC-RBF, a comparative study of effective renal plasma flow (ERPF) measured by 99mTc-MAG3 scintigraphy was performed. ATC-RBF was corrected by kidney volume (ATC-cRBF) for comparison with ERPF.Results: The younger group showed significantly higher ATC-RBF (157.68 ± 38.37 mL/min/100 g) and shorter ATT (961.33 ± 260.87 ms) than the older group (117.42 ± 24.03 mL/min/100 g and 1227.94 ± 226.51 ms, respectively; P < 0.05). A significant correlation was evident between ATC-cRBF and ERPF (P < 0.05, r = 0.47). With suboptimal single PLD (1.5 s) settings, there was no significant correlation between ERPF and kidney volume-corrected RBF calculated from single PLD data.Conclusion: Calculation of ATT and ATC-RBF by pcASL with multiple PLD was feasible in healthy volunteers, and differences in ATT and ATC-RBF were seen between the younger and older groups. Although ATT correction by multiple PLD acquisitions may not always be necessary for RBF quantification in the healthy subjects, the effect of ATT should be taken into account in renal ASL–MRI as debated in brain imaging.
  • Standardized uptake value differences between primary and metastatic lesions in 18F-FDG PET/CT of patients with lung cancer.
    N Kosaka, T Tsuchida, K Tsuji, K Shimizu, H Kimura
    Acta Radiol 56(11) 1329-1335 Nov.  2015 Refereed
  • Evaluation of obliteration of arteriovenous malformations after stereotactic radiosurgery with arterial spin labeling MR imaging
    T.Kodera, Y.Arai, H.Arishima, Y.Higashino, M.Isozaki, K.Tsunetoshi, K.Matsuda, R.Kitai, K.Shimizu, N.Kosaka, T.Yamamoto, H.Shioura, H.Kimura, KI.Kikuta
    Br J Neurosurg 31(6) 641-647 Dec.  2017 Refereed
    T.Kodera
  • Simultaneous acquisition of high-contrast and quantitative liver T1 images using 3D phase-sensitive inversion recovery: a feasibility study
    Y.Fujiwara, H.Maruyama, N.Kosaka, Y.Ishimori
    Acta Radiol 58(8) 899-905 Aug.  2017 Refereed
  • Influence of myocardial count on phase dyssynchrony analysis of gated myocardial perfusion single-photon emission computed tomography
    A.Kita, M.Onoguchi, T.Shibutani, K.Sugimoto, N Kosaka, T.Adachi, H.Kimura
    Nucl Med Commun 40(2) 124-130 Feb.  2019 Refereed

Conference Activities & Talks

  • Clinical Applications of Contrast-Enhanced Optical Imaging in Cancer
    N. Kosaka, M. Mitsunaga, M. Ogawa, P.L. Choyke, H. Kobayashi
    Radiological Society of North America 98th Scientific Assembly and Annual Meeting, Nov.  2012
  • The simultanous calculation of CBF and arterial CBV based on ASL signal obtained with and without vessel suppression
    H.kimura, S.Ishida, T.Matsuda, N.Takei, Y.Fujiwara, N.kosaka
    Japanese Journal of Magnetic Resonance in Medicine Sep.  2018