Iwata Keiko

FacultyResearch Center for Child Mental Development
Teacher OrganizationResearch Center for Child Mental Development
Education and
 Research Organization
Research Center for Child Mental Development
PositionAssistant Professor
Last Updated: 19/11/29 14:49

Researcher Profile & Settings

Name

    Iwata Keiko

Affiliation

  •  Research Center for Child Mental Development Assistant Professor

Education

  • Apr. 2002Mar. 2005Mie University

Academic & Professional Experience

  • Nov. 2012Research Center for Child Mental Development, University of Fukui
  • Apr. 2011Jan. 2012United Graduate School of Child Development
  • Apr. 2008Jan. 2012Research Center for Child Mental Development, Hamamatsu University School of Medicine
  • Feb. 2008Mar. 2008Research Center for Child Mental Development, Hamamatsu University School of Medicine
  • Apr. 2005Feb. 2008Laboratory for Neuronal Differentiation and Regeneration, Center for Developmental Biology, RIKEN Kobe

Association Memberships

    The Japanese Society for Neurochemistry member,Japan Brain Science society member,Japanese Society of Biological Psychiatry member,Society for neuroscience member,THE VITAMIN SOCIETY OF JAPAN member,

Research Activities

Published Papers

  • Microglia-derived neuregulin expression in psychiatric disorders.
    D.Ikawa, M.Makinodan, K.Iwata, M.Ohgidani, T.Kato, Y.Yamashita, K.Yamamuro, S.Kimoto, M.Toritsuka, T.Yamauchi, S.Fukami, H.Yoshino, K.Okumura, T.Tanaka, A.Wanaka, Y.Owada, M.Tsujii, T.Sugiyama, KJ.Tsuchiya, N.Mori, R.Hashimoto, H.Matsuzaki, S.Kanba, T.Kishimoto.
    Brain Behav. Immun. 61 375-385 Mar.  2017 Refereed
  • Tumor necrosis factor-alpha expression in peripheral blood mononuclear cells correlates with early childhood social interaction in autism spectrum disorder.
    M.Makinodan, K.Iwata, D.Ikawa, Y.Yamashita, K.Yamamuro, M.Toritsuka, S.Kimoto, K.Okumura, T.Yamauchi, H.Yoshino, M.Tsujii, T.Sugiyam, KJ.Tsuchiya, N.Mori, H.Matsuzaki, T.Kishimoto.
    Neurochem. Int. 104 1-5 Mar.  2017 Refereed
  • Mismatch in cerebral blood flow and glucose metabolism after the forced swim stress in rats.
    Y.Kameno, K.Suzuki, S.Takagai, K.Iwata, H.Matsuzaki, K.Takahashi, T.Wakuda, Y.Iwata, Y.Magata, N.Mori.
    Acta Neuropsychiatr. 28(6) 352-356 Dec.  2016 Refereed
  • Effect of MK-801 and clozapine on the proteome of cultured human oligodendrocytes.
    JS.Cassoli, K.Iwata, J.Steiner, PC.Guest, CW.Turck, JM.Nascimento, D.Martins-de-Souza
    Front Cell Neurosci. 10(52) Mar.  2016 Refereed
  • Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats.
    Y.Ishibashi, N.Izumo, K.Iwata, T.Morikawa, T.Kameyama, Y.Watanabe, T.Manabe, H.Matsuzaki
    J Brain Sci. 46 5-19 Dec.  2015 Refereed
  • MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia.
    PC.Guest, K.Iwata, TA.Kato, J.Steiner, A.Schmitt, CW.Turck, D.Martins-de-Souza
    Front Cell Neurosci. 9(180) May  2015 Refereed
  • Serum microRNA profiles in children with autism
    Vasu,M. Mundalil, A.Anitha, I.Thanseem, K.Suzuki, K.Yamada, T.Takahashi, T.Wakuda, K. Iwata, M.Tujii, T.Sugiyama, N.Mori
    Mol Autism. 5 40 Jun.  2014 Refereed
  • N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism
    K.Iwata, H.Matsuzaki, T.Tachibana, K.Ohno, S.Yoshimura, H.Takamura, K.Yamada, S.Matsuzaki, K.Nakamura, KJ.Tsuchiya, K.Matsumoto, M.Tsujii, T.Sugiyama, T.Katayama, N.Mori
    Mol Autism May  2014 Refereed
  • Serum microRNA profiles in children with autism
    Vasu, Mahesh Mundalil;Anitha, Ayyappan;Thanseem, Ismail;Suzuki, Katsuaki;Yamada, Kohei;Takahashi, Taro;Wakuda, Tomoyasu;Iwata, Keiko;Tsujii, Masatsugu;Sugiyama, Toshirou;Mori, Norio
    MOLECULAR AUTISM 5 2014
  • N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism
    Iwata, Keiko;Matsuzaki, Hideo;Tachibana, Taro;Ohno, Koji;Yoshimura, Saori;Takamura, Hironori;Yamada, Kohei;Matsuzaki, Shinsuke;Nakamura, Kazuhiko;Tsuchiya, Kenji J.;Matsumoto, Kaori;Tsujii, Masatsugu;Sugiyama, Toshirou;Katayama, Taiichi;Mori, Norio
    MOLECULAR AUTISM 5 2014
  • Fluvoxamine moderates reduced voluntary activity following chronic dexamethasone infusion in mice via recovery of BDNF signal cascades
    Terada, Kazuki;Izumo, Nobuo;Suzuki, Biora;Karube, Yoshiharu;Morikawa, Tomomi;Ishibashi, Yukiko;Kameyama, Toshiki;Chiba, Koji;Sasaki, Noriko;Iwata, Keiko;Matsuzaki, Hideo;Manabe, Takayuki
    NEUROCHEMISTRY INTERNATIONAL 69 9-13 2014
  • Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines.
    M.Mundalil Vasu, A.Anitha, T.Takahashi, I.Thanseem, K.Iwata, T.Asakawa, K.Suzuki.
    PloS one 11(10) e0164425 Oct.  2016 Refereed
    :Evidence suggests neuroprotective effects of fluoxetine, a selective serotonin reuptake inhibitor (SSRI), on the developed neurons in the adult brain. In contrast, the drug may be deleterious to immature or undifferentiated neural cells, although the mechanism is unclear. Recent investigations have suggested that microRNAs (miRNA) may be critical for effectiveness of psychotropic drugs including SSRI. We investigated whether fluoxetine could modulate expressions of neurologically relevant miRNAs in two neuroblastoma SK-N-SH and SH-SY5Y cell lines. Initial screening results revealed that three (miR-489, miR-572 and miR-663a) and four (miR-320a, miR-489, miR-572 and miR-663a) miRNAs were up-regulated in SK-N-SH cells and SH-SY5Y cells, respectively, after 24 hours treatment of fluoxetine (1-25 μM). Cell viability was reduced according to the dose of fluoxetine. The upregulation of miR-572 and miR-663a was consistent in both the SH-SY5Y and SK-N-SH cells, confirmed by a larger scale culture condition. Our data is the first in vitro evidence that fluoxetine could increase the expression of miRNAs in undifferentiated neural cells, and that putative target genes of those miRNAs have been shown to be involved in fundamental neurodevelopmental processes.
  • Perinatal asphyxia in rat alters expression of novel schizophrenia risk genes.
    A.Paparelli, K.Iwata, T.Wakuda, CO.Iyegbe, RM.Murray, N.Takei.
    Front Mol Neurosci. 10(341) Oct.  2017 Refereed
  • PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
    MJ.Xie, Y.Ishikawa, H.Yagi, T.Iguchi, Y.Oka, K.Kuroda, K.Iwata, H.Kiyonari, S.Matsuda, H.Matsuzaki, M.Yuzaki, Y.Fukazawa and M.Sato.
    Sci Rep. 9(1) 4305 Mar.  2019 Refereed
  • Mitochondrial Involvement in Mental Disorders; Energy Metabolism, Genetic, and Environmental Factors.
    K.Iwata
    Methods Mol Biol. 1916 41-48 Dec.  2018 Refereed
  • Characterization of an Animal Model of Autism and Social Interaction.
    K.Iwata
    Methods Mol Biol. 1916 149-155 Dec.  2018 Refereed
  • Studies of a neuronal cell line as a model of psychiatric disorders.
    K.Iwata
    Methods Mol Biol. 1735 231-238 Jan.  2018 Refereed

Conference Activities & Talks

  • Exploring the role of mitochondrial dynamics in developmental and psychiatric disorders.
    K.Iwata, L.Scorrano
    15th VIMM Annual Retreat Feb.  2017
  • Specific Hypolipidemia caused by VLDL degradation in Children with ASD.
    H.Matsuzaki, K.Iwata, K.Nakamura, M.Tsujii, N.Mori
    The Society for Neuroscience 46th annual meeting Nov.  2016 The Society for Neuroscience
  • Phosphoinositide responsive Phldb2 regulates synaptic plasticity.
    MJ.Xie, H.Yagi, T.Iguchi, Y.Oka, Y.Fukazawa, H.Matsuzaki, K.Iwata, Y.Ishikawa, M.Sato
    The Society for Neuroscience 46th annual meeting Nov.  2016 The Society for Neuroscience
  • Abnormal Expression of a SERT-Binding Protein, NSF, in Autism: Implications for Pathophysiology in Autism
    K.Iwata, H.Matsuzaki, K.Nakamura, T.Katayama, N.Mori
    2015 International Meeting for Autism Research May  2015
  • NSF interact with SEAT and modulates its trafficking : implications for path ophysiology in autism.
    K.Iwata, H.Matsuzaki, K.Tachibana, K.Nakamura, T.Katayama, N.Mori
    Society for Neuroscience 2015 Oct.  2015
  • Analysis of neurotransmitters in the brain and behavioral abnormalities of offsprings from stressed mother in mice
    Y.Watanabe, T.Ito, K. Iwata, H.Matsuzaki, Y.Konishi, H.Ikeda, K.Murase
     Mar.  2015
  • Modulation of the serotonin transporter by interaction with N-ethylmaleimide-sensitive factor.
    K.Iwata, H.Matsuzaki, T.Tachibana, T.Katayama, N.Mori
    2014 International Meeting for Autism Research May  2014
  • Specific Hypolipidemia Caused By VLDL Lipolysis in Children with ASD.
    H.Matsuzaki, K. Iwata, K.Nakamura, M,Tsujii, N.Mori
    2014 International Meeting for Autism Research May  2014
  • Alteration of the expression balance of hnRNP C1 and C2 changes the expression of myelination- and schizophrenia-related genes in the human oligodendrocytic cell line.
    K.Iwata, H.Matsuzaki, T.Manabe, D.Martins-de-Souza, N.Takei
    SIRS2014(The 4th Biennial Schizophrenia International Research Society Conference) Apr.  2014
  • Modulation of the serotonin transporter by interaction with N-ethylmaleimide-sensitive factor.
    K. Iwata, H.Matsuzaki, T.Tachibana, T.Katayama, N.Mori
    Neuro2013 Jun.  2013
  • Specific hypolipidemia pattern in individuals with autism spectrum disorder.
    H.Matsuzaki, K. Iwata, T.Tachibana, T.Katayama, N.Mori
    11th World Congress of Biological Psychiatry Jun.  2013
  • Genome-wide DNA methylation profiles in post-mortem brains from subjects with autism.
    K. Iwata, K.Nakamura, H.Matsuzaki, K.Nakamura, K.Hata, N.Mori
    International Meeting for Autism Research May  2013
  • Studying cultured astrocytes, oligodendrocytes and neurons to reveal where are the proteomic differences observed in schizophrenia brains.
    D.Martins-de-Souza, K. Iwata, A.Schmitt, P.Falkai, C.W.Turck
     Apr.  2013
  • Genome-wide DNA methylation profiles in post-mortem brains from subjects with autism.
    K. Iwata, H.Matsuzaki, K.Nakabayashi, K.Nakamura, K.Hata, N.Mori
    The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry / 55th Annual Meeting of the Japanese Society for Neurochemistry Sep.  2012
  • Serum levels of anterior pituitary hormones in children with autism.
    K. Iwata, H.Matsuzaki, N.Mori
    The 11th annual International Meeting for Autism Research May  2012
  • Serum levels of anterior pituitary hormones in children with autism.
    H.Matsuzaki, K. Iwata, N.Mori
    The 11th annual International Meeting for Autism Research May  2012
  • Serum levels of anterior pituitary hormones in children with autism. the 54th Annual.
    H.Matsuzaki, K.Iwata, N.Mori
    Meeting of the Japanese Society for Neurochemistry Sep.  2011
  • Alteration of the expression balance of hnRNP C1 and C2 changes the expression of myelination-related genes in the human neuroblastoma cell line.
    K.Iwata, H.Matsuzaki, N.Mori
    the 54th Annual Meeting of the Japanese Society for Neurochemistry Sep.  2011
  • VLDL-specific hypolipidemia pattern in human subjects with autism and autistic rodent models.
    H.Matsuzaki, K.Iwata, KJ.Tsuchiya, H.Itoh, N.Mori
    The 7th World Congress on Developmental Origins of Health and Disease Sep.  2011
  • Dysregulation of glutamatergic biosynthetic pathway in subjects wuth autism.
    C.Shimmura, S.Suda, KJ.Tsuchiya, K.Hashimoto, K.Ohno, H.Matsuzaki, K.Iwata, Y.Kameno, K.Nakamura, N.Takei, N.Mori
    The Society for Neuroscience 40th annual meeting Nov.  2010
  • Serum adipokine levels in children with autism.
    H.Matsuzaki, A.Fujita-Shimizu, K.Iwata, S.Suda, C.Shimmura, Y.Kameno, N.Mori
    The Society for Neuroscience 40th annual meeting Nov.  2010
  • VLDLR-overexpressing transgenic rats: evaluation as an animal models of autism.
    K.Iwata, H.Matsuzaki, N.Izumo, Y.Ichitani, N.Takei, N.Mori
    The Society for Neuroscience 40th annual meeting Nov.  2010
  • VLDLR overexpression rat: evaluation as an animal model of autism.
    K.Iwata, H.Matsuzaki, N.Izumo, Y.Ichitani, N.Mori
    The 53rd Annual Meeting of the Japanese Society for Neurochemistry, Sep.  2010
  • Dyslipidemia in male patients with high-functioning autism.
    H.Matsuzaki, K.Iwata, S.Suda, KJ.Tsuchiya, K.Suzuki, K.Nakamura, M.Tsujii, N.Takei, N.Mori
    The 9th annual International Meeting for Autism Research May  2010
  • Lipid metabolism analysis of serum in male with autism.
    H.Matsuzaki, K.Iwata, A.Fujita-Shimizu, N.Mori
    The 32nd Annual Meeting of the Japanese Society of Biological Psychiatry Jan.  2010
  • Serotonin related gene expression changes in subjects with autism: A postmortem brain study.
    S.Suda, K.Iwata, A.Anitha, I.Thanseem, H.Matsuzaki, Y.Kameno, K.Nakamura, N.Mori, N.Takei
    The Society for Neuroscience 39th annual meeting Jan.  2009
  • Dyslipidemia in male patients with high-functioning autism.
    H.Matsuzaki, K.Iwata, S.Suda, T.Miyachi, K.Suzuki, K.Nakamura, M.Tsujii, N.Takei, N.Mori
    The Society for Neuroscience 39th annual meeting Jan.  2009
  • Serotonin transporter and serotonin related gene expression in autism.
    S.Suda, K.Iwata, A.Anitha, I.Thanseem, K.Nakamura, H.Matsuzaki, Y.Iwata, S.Yamamoto, K.Suzuki, N.Takei, K.Koizumi, N.Mori
    The 38th annual meeting of the Society for Neuroscience Nov.  2008
  • The trial to establish novel animal model for autism by focusing on reelin signal.
    H.Matsuzaki, K.Iwata, K.Takebayashi, G.Sugihara, K.Suzuki, K.Nakamura, M.Kawai, M.Tsujii, N.Takei, N.Mori
    The 35th annual meetings of Japan Brain Science Society Jun.  2008
  • Abnormal membrane protein trafficking in the autistic like the N-ethylmaleimide sensitive factor knockout mice.
    MJ.Xie, K.Iwata, Y.Fukazawa and H.Matsuzaki
    The Society for Neuroscience 48th annual meeting Nov.  2018
  • Exploring the role of mitochondrial dynamics in developmental and psychiatric disorders.
    K.Iwata and L.Scorrano
    Retreat of Biology department Jan.  2019