AOKI Kouji

FacultyBiochemistry and Bioinformative Sciences, Pharmacology
Teacher OrganizationBiochemistry and Bioinformative Sciences
Education and
 Research Organization
Faculty of Medical Sciences, School of Medicine
Last Updated: 19/07/23 18:59

Researcher Profile & Settings


    AOKI Kouji


  •  Biochemistry and Bioinformative Sciences, Pharmacology Professor


  • Apr. 2001Mar. 2004Kyoto University
  • Apr. 1999Mar. 2001The University of Tokyo
  • Apr. 1995Mar. 1999The University of Tokyo Fuculty of Pharmaceutical Sciences


  • Ph.D.

Academic & Professional Experience

  • Mar. 2014Department of Pharmacology,Division of Medicine,Faculty of Medical Sciences,University of Fukui Professor

Association Memberships

    Japanese Society for Immunology member,The Japanese Pharmacological Society member,The Japanese Cancer Association member,The Molecular Biology Society of Japan member,

Research Activities

Published Papers

  • Blocking LC3 lipidation and ATG12 conjugation reactions by ATG7 mutant protein containing C572S.
    Nitta A1, Hori K2, Tanida I3, Igarashi A1, Deyama Y4, Ueno T5, Kominami E6, Sugai M7, Aoki K8.
    Biochem Biophys Res Commun. 508(2) 521-526 Jan.  2019 Refereed
  • Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation
    Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, Kuno T, Takamatsu M, Aoki K, Taketo MM, Kim YJ, Hara A, and Yamada Y
    Carcinogenesis 36(7) 719-729 2015 Refereed
  • Mitochondrial function provides instructive signals for activation-induced B-cell fates
    Jang KJ, Mano H, Aoki K, Hayashi T, Muto A, Nambu Y, Takahashi K, Itoh K, Taketani S, Nutt SL, Igarashi K, Shimizu A, and Sugai M
    Nature Communications 10(6) 6750 2015 Refereed
  • In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues
    Nambu Y, Hayashi T, Jang KJ, Aoki K, et al
    Scientific Report Jan.  2012 Refereed
  • Runx3 is reuired for full activation of regulatory T cells to prevent colitis-associated tumor formation
    Aoki K, Sugai M, Osato M, Nambu Y, Ito K, Taketo MM, Shimizu A
    Journal of Immunology 186(11) 6515-20 2011 Refereed
  • Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling
    Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, Sakai Y, Hashida H, Takabayashi A, Sasaki M, Robine S, Itoh K, Yoshioka K, Kakizaki F, Kitamura T, Oshima M, Taketo MM
    Cancer Cell 19(1) 125-37 2011 Refereed
  • Suppression of colonic polyposis by homeoprotein CDX2 through its nontranscriptional function that stabilizes p27Kip1
    Aoki K, Kakizaki F, Sakashita H, Manabe T, Aoki M, Taketo MM
    Cancer Research 71(2) 593-602 2011 Refereed
  • CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium
    Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M, Taketo MM
    Gastroenterology 138(2) 627-35 2010 Refereed
  • Reduced Level of Smoothened Suppresses Intestinal Tumorigenesis by Down-Regulation of Wnt Signaling
    Arimura S, Matsunaga A, Kitamura T, Aoki K, Aoki M, Taketo MM
    Gastroenterology 137(2) 629-38 2009 Refereed
  • Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcΔ716 mice
    Fujishita T, Aoki K, Lane HA, Aoki M, Taketo MM
    Proc. Natl. Acad. Sci. USA. 105(36) 13544-13549 2008 Refereed
  • Chromosomal instability by β-catenin/TCF transcription in APC or β-catenin mutant cells
    Aoki K, Aoki M, Sugai M, Harada N, Miyoshi H, Tsukamoto T, Mizoshita T, Tatematsu M, Seno H, Chiba T, Oshima M, Hsieh CL, Taketo MM
    Oncogene 26(24) 3511-3520 2007 Refereed
  • Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene
    Aoki K, Taketo MM
    Journal of Cell Science 120(19) 3327-3335 2007 Refereed
  • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Δ716Cdx2+/- compound mutant mice
    Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM
    Nature Genetics 35(4) 323-330 2003 Refereed

Books etc

  • Roles of the epithelial autophagy in the intestinal mucosal barrier
    Aoki K*, Sugai M
    Springer Press 2016
  • Tissue-specific transgenic, conditional knockout and knock-in mice of genes in the canonical Wnt signaling pathway.
    Aoki K, Taketo MM
    Methods in Molecular Biology 2008

Conference Activities & Talks

  • Blocking intestinal cancer stemness and malignant progression by intestine-specific homeoproteins
    Aoki K, Hori K
    Hokuriku Epigenetics 2016
  • Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX2
    Aoki K
    75th The Japanese Cancer Association Oct.  2016
  • Enhanced intestinal mucosal barrier function by homeoprotein CDX2 through autophagy activation
    K.Aoki, et al
    39th The Molecular Biology Society of Japan Dec.  2016
  • Suppression of intestinal cancer stemness and malignant progression by intestine-specific homeoproteins CDX1 and CDX2
    Koji A
    The19th The Japanese Cancer Association Jan.  2015
  • Roles of intestine-specific CDX2 in the intestinal epithelial barrier
    Koji A
    The43th The Japan Society for Immunology Dec.  2014
  • Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier
    Koji A
    The37th The Molecular Biology Society of Japan Nov.  2014
  • Roles of intestine-specific homeoprotein CDX2 in the intestinal epithelial barrier.
    Aoki K, et al
    ST-CREST International Symposium, Frontiers in Immunology and Inflammation: From Molecules to Disease Feb.  2013

Social Contribution


  • 福井大研究でも注目 クローン病の治療法Oct. 2016 福井、日刊県民福井、中日、中日夕刊