丁 ミンヨン

所属部署名情動認知発達研究部門
教員組織情動認知発達研究部門
教育研究組織子どものこころの発達研究センター
職名特命助教
更新日: 19/02/07 09:06

研究者基本情報

氏名

    丁 ミンヨン
    ジョン ミンヨン
    Jung Minyoung

所属

  •  情動認知発達研究部門 特命助教
  •  子どものこころの発達研究センター 特命助教

研究活動情報

論文

  • Decreased structural connectivity and resting-state brain activity in the lateral occipital cortex is associated with social communication deficits in boys with autism spectrum disorder.
    Jung Minyoung;Tu Yiheng;Lang Courtney Amanda;Ortiz Ana;Park Joel;Jorgenson Kristen;Kong Xue-Jun;Kong Jian
    NeuroImage 2017年 査読有り
  • Catechol-O-methyltransferase polymorphism is associated with the cortico-cerebellar functional connectivity of executive function in children with attention-deficit/hyperactivity disorder.
    Mizuno Yoshifumi;Jung Minyoung;Fujisawa Takashi X;Takiguchi Shinichiro;Shimada Koji;Saito Daisuke N;Kosaka Hirotaka;Tomoda Akemi
    Scientific reports 7(1) 2017年 査読有り
  • Symptoms in individuals with adult-onset ADHD are masked during childhood.
    Kosaka Hirotaka;Fujioka Toru;Jung Minyoung
    European archives of psychiatry and clinical neuroscience 2018年
  • Differences in Brain Hemodynamics in Response to Achromatic and Chromatic Cards of the Rorschach: A fMRI Study.
    Ishibashi Masahiro;Uchiumi Chigusa;Jung Minyoung;Aizawa Naoki;Makita Kiyoshi;Nakamura Yugo;Saito Daisuke N
    Rorschachiana 37(1) 2016年
    : In order to investigate the effects of color stimuli of the Rorschach inkblot method (RIM), the cerebral activity of 40 participants with no history of neurological or psychiatric illness was scanned while they engaged in the Rorschach task. A scanned image of the ten RIM inkblots was projected onto a screen in the MRI scanner. Cerebral activation in response to five achromatic color cards and five chromatic cards were compared. As a result, a significant increase in brain activity was observed in bilateral visual areas V2 and V3, parietooccipital junctions, pulvinars, right superior temporal gyrus, and left premotor cortex for achromatic color cards (p< .001). For the cards with chromatic color, significant increase in brain activity was observed in left visual area V4 and left orbitofrontal cortex (p< .001). Furthermore, a conjoint analysis revealed various regions were activated in responding to the RIM. The neuropsychological underpinnings of the response process, as described by Acklin and Wu-Holt (1996), were largely confirmed.
  • The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria.
    Wang Yuming;Fang Jiliang;Song Ping;Bao Yan;Song Wenwen;Liu Jiao;Lang Courtney;Jorgenson Kristen;Jung Minyoung;Shen Dong;Li Shasha;Sun Ruirui;Ding Xu;Yang Jiao;Meng Xiao;Wang Ning;Yan Zhifang;Yan Yuhe;Kong Qian;Dong Ying;Cui Fangyuan;Tu Yiheng;Cui Bingnan;Kong Jian
    Cerebellum (London, England) 17(5) 2018年03月 査読有り
    :Chronic spontaneous urticaria (CSU) is a common itchy skin disease. Despite its prevalence, the neuropathology of CSU is uncertain. In this study, we explored resting state functional connectivity (rs-FC) changes in CSU, as well as how the symptom changes following intervention can modulate rs-FC. Forty patients and 40 healthy controls (HCs) were recruited. Following an intervention, 32 patients participated in a second scan approximately 6 weeks after the first scan. Compared with healthy controls, CSU subjects exhibited higher regional homogeneity (ReHo) values in the cerebellum, which were positively associated with urticaria activity scores over 7 days (UAS7) at baseline. After an intervention accompanied with clinical improvement, we found that ReHo values decreased at the cerebellum and increased at the bilateral primary somatosensory cortex (SI)/primary motor cortex (MI)/supplementary motor area (SMA). Using the cerebellum as a seed, CSU subjects exhibited increased rs-FC with reward regions when compared with HCs and exhibited decreased rs-FC at the right orbitofrontal cortex and right sensorimotor region following the intervention. The improvement rate values were positively associated with reduced rs-FC values in the two regions. Using the cluster of SI/MI/SMA as a seed, CSU patients exhibited decreased rs-FC with the left putamen, caudate, accumbens, and thalamus following the intervention. These results demonstrate the altered cerebellar activity and cerebellum-reward-sensorimotor loops in CSU.
  • The Effects of COMT Polymorphism on Cortical Thickness and Surface Area Abnormalities in Children with ADHD.
    Jung Minyoung;Mizuno Yoshifumi;Fujisawa Takashi X;Takiguchi Shinichiro;Kong Jian;Kosaka Hirotaka;Tomoda Akemi
    Cerebral cortex (New York, N.Y. : 1991) 2018年01月 査読有り
    :The catechol-O-methyltransferase (COMT) gene is associated with frontal cortex development and the pathophysiology of attention-deficit/hyperactivity disorder (ADHD). However, how the COMT gene impacts brain structure and behavior in ADHD remains unknown. In the present study, we identify the effect of COMT on cortical thickness and surface area in children with ADHD and children with typically developing (TD) using a machine learning approach. In a sample of 39 children with ADHD and 34 age- and IQ-matched TD children, we found that cortical thickness and surface area differences were predominantly observed in the frontal cortex. Furthermore, a path analysis revealed that a COMT genotype affected abnormal development of the frontal cortex in terms of both cortical thickness and surface area and was associated with working memory changes in children with ADHD. Our study confirms that the role of COMT in ADHD is not restricted to the development of behavior but may also affect the cortical thickness and surface area. Thus, our findings may help to improve the understanding of the neuroanatomic basis for the relationship between the COMT genotype and ADHD pathogenesis.

講演・口頭発表等

  • Multimodal neuroimaging アプローチにおける自閉症スペクトラム障害の診断補助
    丁ミンヨン、小坂浩隆、Jian Kong
    第58回日本児童青年精神医学会総会 2017年10月
  • ADHD児におけるCOMT遺伝子多型と大脳皮質-小脳の実行機能ネットワークの関連
    水野賀史、丁ミンヨン、藤澤隆史、島田浩二、齋藤大輔、小坂浩隆、友田明美
    第44回日本脳科学会 2017年10月
  • Structural connectivity and resting-state brain activity of the lateral occipital cortex impact social communication deficit in boys with autism spectrum disorder
    Jung M, Kosaka H, Kong J.
    International Autism Conference Tokyo 2017 2017年10月
  • Surfaced based shared and distinct resting functional connectivity between attention-deficit/hyperactivity disorder and autism spectrum disorder
    Jung M, Kosaka H, Kong J.
    International Autism Conference Tokyo 2017 2017年10月